在全球帕金森病遗传学计划 (GP2) 中定义散发性帕金森病的病因,npj Parkinson's Disease

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在全球帕金森病遗传学计划 (GP2) 中定义散发性帕金森病的病因
npj Parkinson's Disease ( IF 6.7 ) Pub Date : 2023-09-12 , DOI: 10.1038/s41531-023-00533-w
Clodagh Towns ₁ , Madeleine Richer ₁ , Simona Jasaityte ₁ , Eleanor J Stafford _{1,

2} , Julie Joubert ₁ , Tarek Antar ₃ , Alejandro Martinez-Carrasco _{1,

2} , Mary B Makarious _{1,

3,

4} , Bradford Casey _{5,

6} , Dan Vitale _{4,

7,

8} , Kristin Levine _{7,

8} , Hampton Leonard _{3,

7,

8,

9} , Caroline B Pantazis _{4,

7} , Laurel A Screven ₇ , Dena G Hernandez ₃ , Claire E Wegel ₁₀ , Justin Solle ₅ , Mike A Nalls _{3,

4,

7,

8} , Cornelis Blauwendraat _{4,

7,

11} , Andrew B Singleton _{3,

7,

12} , Manuela M X Tan ₁₃ , Hirotaka Iwaki _{3,

7,

8} , Huw R Morris _{1,

2} ,

Affiliation

Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.
University College London, London, UK.
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health, Bethesda, MD, USA.
Department of Clinical Research, Michael J. Fox Foundation for Parkinson's Research, New York City, NY, USA.
The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Data Tecnica International, Washington, DC, USA.
National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Integrative Genomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
National Institute on Aging, Bethesda, MD, USA.
Department of Neurology, Oslo University Hospital, Oslo, Norway.

全球帕金森氏症遗传学计划 (GP2) 将对来自世界各地的 150,000 多名参与者进行基因分型，并整合遗传和临床数据以用于大规模分析，以极大地扩展我们对帕金森氏症遗传结构的理解。本报告详细介绍了队列整合到 GP2 复杂臂中的工作流程，并与我们在配套论文中对单基因中心的概述一起，为建立大规模合作研究联盟提供了通用的蓝图。

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更新日期：2023-09-14

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