用于伤口敷料的含 Ag 和 MoO3 纳米粒子的聚丙烯腈纳米纤维膜,ACS Applied Nano Materials

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用于伤口敷料的含 Ag 和 MoO3 纳米粒子的聚丙烯腈纳米纤维膜
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-09-11 , DOI: 10.1021/acsanm.3c03435
Muhammad Farooq ₁ , Maira Khalid ₁ , Yabuta Yoshinori ₁ , Feifei Wang ₁ , Muhammad Asim Iqbal ₁ , Muhammad Nauman Sarwar ₁ , Gopiraman Mayakrishnan ₂ , Ick Soo Kim ₂

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在此，我们报告了不同还原剂对Ag-MoO ₃ /聚丙烯腈纳米纤维的影响，因其作为先进伤口敷料的巨大潜力。纳米纤维用NaOH、NaBH ₄、柠檬酸钠和紫外光处理，并评估其性能。水接触角测量表明，NaOH 处理导致表面可润湿性较差，而 NaBH ₄和柠檬酸钠处理则导致表面润湿性更强。紫外线处理导致表面润湿性略有增加。抗菌抑菌圈试验表明，NaOH和UV处理对大肠杆菌和枯草芽孢杆菌均有显着的抑制作用，而NaBH ₄柠檬酸钠处理显示出中等的抑制作用。此外，银释放曲线表明银离子随着时间的推移持续释放，柠檬酸钠处理表现出更高的释放速率。MoO ₃ /聚丙烯腈表现出显着较低的应力值，比空白聚丙烯腈（PAN）纳米纤维低73%。应力值的降低对于伤口敷料是有利的，因为它可以改善伤口部位的灵活性和顺应性。总的来说，这些发现提供了对不同处理下Ag-MoO ₃ /聚丙烯腈纳米纤维的表面润湿性、抗菌性能和银离子释放能力的深入了解，凸显了它们在伤口敷料应用中的潜力。

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Ag and MoO3 Nanoparticle-Containing Polyacrylonitrile Nanofiber Membranes for Wound Dressings

Herein, we report the effect of different reducing agents on Ag-MoO₃/polyacrylonitrile nanofibers for their promising potential as advanced wound dressings. The nanofibers were treated with NaOH, NaBH₄, sodium citrate, and UV light, and their properties were evaluated. Water contact angle measurements revealed that NaOH treatment resulted in a less wettable surface, while NaBH₄ and sodium citrate treatments led to more wettable surfaces. UV light treatment induced a slight increase in the surface wettability. Antibacterial inhibition zone tests showed that NaOH and UV treatments exhibited significant inhibitory effects against both Escherichia coli and Bacillus subtilis, while NaBH₄ and sodium citrate treatments displayed moderate inhibitory effects. Moreover, silver release profiles demonstrated a sustained release of silver ions over time, with sodium citrate treatment exhibiting a higher release rate. MoO₃/polyacrylonitrile displayed a substantially lower stress value, 73% less than that of the blank polyacrylonitrile (PAN) nanofiber. This decrease in the stress value is advantageous for wound dressings, as it allows for improved flexibility and conformability to the wound site. Overall, these findings provide insights into the surface wettability, antimicrobial properties, and silver ion release capabilities of Ag-MoO₃/polyacrylonitrile nanofibers under different treatments, highlighting their potential for wound dressing applications.

更新日期：2023-09-11

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