Dynapenic Abdominal Obesity and Risk of Heart Disease among Middle-Aged and Older Adults: A Prospective Cohort Study,The Journal of Nutrition, Health & Aging

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Dynapenic Abdominal Obesity and Risk of Heart Disease among Middle-Aged and Older Adults: A Prospective Cohort Study
The Journal of Nutrition, Health & Aging ( IF 4.3 ) Pub Date : 2023-09-08 , DOI: 10.1007/s12603-023-1975-0
X Wang ₁ , J Jiang , W Hu , Y Hu , L-Q Qin , Y Hao , J-Y Dong

Affiliation

Objectives

The vicious cycle of dynapenia and abdominal obesity may have synergistic detrimental impacts on health. We aim to investigate the prospective association between dynapenic abdominal obesity and the risk of heart disease among middle-aged and older adults.

Design

A prospective cohort study.

Setting

English Longitudinal Study of Ageing, 2002–2019.

Participants

A total of 4734 participants aged 50 years and older were included.

Measurements

Individuals were divided into non-dynapenia/non-abdominal obesity (ND/NAO), non-dynapenia/abdominal obesity (ND/AO), dynapenia/non-abdominal obesity (D/NAO), and dynapenia/abdominal obesity (D/AO) according to grip strength and waist circumference at baseline. The Cox proportional hazards models were used to obtain the hazard ratios (HRs) of incident heart disease associated with dynapenia and abdominal obesity after adjusting for potential confounding factors.

Results

During a median follow-up of 9.5 years, 1040 cases of heart disease were recorded. Compared with ND/NAO group, the multivariable HRs were 1.05 (0.92, 1.21) for ND/AO group, 1.31 (0.96, 1.81) for D/NAO group, and 1.39 (1.03, 1.88) for D/AO group. The significant association of D/AO with incident heart disease was detected in women but not in men [HR = 1.55 (1.07, 2.24) and 1.06 (0.60, 1.88), respectively]. Among middle-aged adults, significant associations of D/NAO and D/AO with incident heart disease were observed [HR = 2.46 (1.42, 4.29) and 1.74 (1.02, 2.97), respectively].

Conclusion

Both D/NAO and D/AO might increase the risk of developing heart disease, highlighting the importance of dynapenia and obesity early screening for heart disease prevention.

中文翻译：

中老年人动力性腹部肥胖与心脏病风险：一项前瞻性队列研究

目标

缺乏性缺乏和腹部肥胖的恶性循环可能对健康产生协同有害影响。我们的目的是调查中老年人中无缺乏性腹部肥胖与心脏病风险之间的前瞻性关联。

设计

一项前瞻性队列研究。

环境

英国老龄化纵向研究，2002-2019。

参加者

共有 4734 名 50 岁及以上的参与者被纳入其中。

测量

将个体分为非乏力/非腹部肥胖（ND/NAO）、非乏力/腹部肥胖（ND/AO）、乏力/非腹部肥胖（D/NAO）和乏力/腹部肥胖（D/ AO）根据基线的握力和腰围。在调整潜在的混杂因素后，使用 Cox 比例风险模型获得与无性缺乏和腹部肥胖相关的心脏病事件的风险比 (HR)。

结果

在中位随访 9.5 年期间，记录了 1040 例心脏病病例。与ND/NAO组相比，ND/AO组多变量HR为1.05（0.92，1.21），D/NAO组为1.31（0.96，1.81），D/AO组为1.39（1.03，1.88）。在女性中检测到 D/AO 与心脏病发生率显着相关，但在男性中则不然 [HR 分别 = 1.55 (1.07, 2.24) 和 1.06 (0.60, 1.88)]。在中年成年人中，观察到 D/NAO 和 D/AO 与心脏病发病率显着相关 [HR 分别 = 2.46 (1.42, 4.29) 和 1.74 (1.02, 2.97)]。