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Galactomannan polysaccharide as a biotemplate for the synthesis of zinc oxide nanoparticles with photocatalytic, antimicrobial and anticancer applications
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2023-09-09 , DOI: 10.1016/j.ijbiomac.2023.126787
Amol Kahandal 1 , Sanyukta Chaudhary 1 , Saakshi Methe 1 , Pratik Nagwade 2 , Aruna Sivaram 1 , Chandrakant K Tagad 1
Affiliation  

Biotemplates provide a facile, rapid, and environmentally benign route for synthesizing various nanostructured materials. Herein, Locust Bean Gum (LBG), a galactomannan polysaccharide, has been used as a biotemplate for synthesizing ZnO nanoparticles (NPs) for the first time. The composition, structure, morphology, and bandgap of ZnO were investigated by Energy Dispersive X-ray Spectroscopy (EDX), X-Ray Photoelectron Spectroscopy (XPS), X-ray powder diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and UV–vis spectroscopy. XRD data showed single-phase crystalline hexagonal NPs. FTIR spectra confirmed the presence of M-O bonding in the sample. At a concentration of 0.5 mg/mL the NPs can degrade Rhodamine B under sunlight, displaying excellent photocatalytic activity. These NPs exhibited antimicrobial activity in both Staphylococcus aureus and Bacillus subtilis. Significant cell death was observed at 500 μg/mL, 250 μg/mL, 125 μg/mL and 62.5 μg/mL of NP in breast cancer, ovarian cancer and lung cancer cell lines. Wound healing assay showed that the NPs significantly blocked the cell migration at a concentration as low as 62.5 μg/mL in all three cell lines. Further optimization of the nanostructure properties will make it a promising candidate in the field of nano-biotechnology and bioengineering owing to its wide range of potential applications.



中文翻译:

半乳甘露聚糖作为生物模板,用于合成具有光催化、抗菌和抗癌应用的氧化锌纳米颗粒

生物模板为合成各种纳米结构材料提供了一种简便、快速且环境友好的途径。在此,刺槐豆胶(LBG),一种半乳甘露聚糖多糖,首次被用作合成氧化锌纳米粒子(NPs)的生物模板。通过能量色散X射线光谱(EDX)、X射线光电子能谱(XPS)、X射线粉末衍射(XRD)、扫描电子显微镜(SEM)、透射电镜研究了ZnO的组成、结构、形貌和带隙。电子显微镜 (TEM) 和紫外可见光谱。XRD 数据显示单相结晶六方纳米颗粒。FTIR 光谱证实样品中存在 MO 键合。在0.5 mg/mL浓度下,NPs可以在阳光下降解罗丹明B,表现出优异的光催化活性。这些纳米颗粒对金黄色葡萄球菌枯草芽孢杆菌均表现出抗菌活性。在乳腺癌、卵巢癌和肺癌细胞系中,500 μg/mL、250 μg/mL、125 μg/mL 和 62.5 μg/mL NP 时观察到显着的细胞死亡。伤口愈合测定表明,在所有三种细胞系中,NPs 在浓度低至 62.5 μg/mL 时均能显着阻断细胞迁移。由于其广泛的潜在应用,纳米结构特性的进一步优化将使其成为纳米生物技术和生物工程领域有前途的候选者。

更新日期:2023-09-09
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