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Natural Existence and Bioactivity of Flavonoids: Synthetic Strategies and Mechanistic Pathways
Mini-Reviews in Organic Chemistry ( IF 1.9 ) Pub Date : 2023-09-08 , DOI: 10.2174/1570193x21666230901110030
Shivangi Sharma 1 , Pankaj Kumar Mishra 2 , Shivendra Singh 1
Affiliation  

: A class of chemicals known as flavonoids is widely distributed in various portions of plants, cereals, and vegetables. They have varied phenolic structures and these flavonoid molecules are known for the well-being improvement in living things. Today, a wide range of pharmaceutical, medicinal, & cosmetic materials possessed these key ingredients, known as flavonoids. Flavonoids can modulate the bioactivity of essential enzymes & their properties such as anti-mutagenic, anti-inflammatory, anti-oxidative, & anti-carcinogenic. The current patterns of flavonoid in research & development helps in the identification, isolation, characterization, & functions of flavonoids as well as their applications for better biological activities. In this article, we have discussed the natural existence and structural frameworks of the different classes of potential bioactive flavonoids. In addition to this, different synthetic strategies, and their mechanistic pathways for the preparation of different classes of flavonoids are also discussed thoroughly here. Owing to its tremendous natural existence and bioactivity, more research is still needed to further explore the usefulness of flavonoids for human wellness. The major challenge with the study of such flavonoids is the diversity of molecular structures & scarcity of data on their bioavailability. However, this article will be helpful for understanding the chemical aspect and several potential bioactivities of flavonoids

中文翻译:

黄酮类化合物的天然存在和生物活性:合成策略和机制途径

:一类称为类黄酮的化学物质广泛分布于植物、谷物和蔬菜的各个部分。它们具有不同的酚类结构,这些类黄酮分子因改善生物的健康而闻名。如今,多种药物、药用和化妆品材料都含有这些关键成分,称为类黄酮。黄酮类化合物可以调节必需酶的生物活性及其特性,例如抗突变、抗炎、抗氧化和抗癌。当前黄酮类化合物的研究和开发模式有助于黄酮类化合物的鉴定、分离、表征和功能,以及它们在更好的生物活性方面的应用。在本文中,我们讨论了不同类别的潜在生物活性黄酮类化合物的自然存在和结构框架。除此之外,本文还深入讨论了不同的合成策略及其制备不同类别黄酮类化合物的机制途径。由于其巨大的自然存在和生物活性,仍需要更多的研究来进一步探索类黄酮对人类健康的有用性。研究此类黄酮类化合物的主要挑战是分子结构的多样性和其生物利用度数据的缺乏。然而,本文将有助于了解类黄酮的化学方面和几种潜在的生物活性 此处还深入讨论了它们制备不同类别黄酮类化合物的机制途径。由于其巨大的自然存在和生物活性,仍需要更多的研究来进一步探索类黄酮对人类健康的有用性。研究此类黄酮类化合物的主要挑战是分子结构的多样性和其生物利用度数据的缺乏。然而,本文将有助于了解类黄酮的化学方面和几种潜在的生物活性 此处还深入讨论了它们制备不同类别黄酮类化合物的机制途径。由于其巨大的自然存在和生物活性,仍需要更多的研究来进一步探索类黄酮对人类健康的有用性。研究此类黄酮类化合物的主要挑战是分子结构的多样性和其生物利用度数据的缺乏。然而,本文将有助于了解类黄酮的化学方面和几种潜在的生物活性 研究此类黄酮类化合物的主要挑战是分子结构的多样性和其生物利用度数据的缺乏。然而,本文将有助于了解类黄酮的化学方面和几种潜在的生物活性 研究此类黄酮类化合物的主要挑战是分子结构的多样性和其生物利用度数据的缺乏。然而,本文将有助于了解类黄酮的化学方面和几种潜在的生物活性
更新日期:2023-09-08
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