Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy,Angewandte Chemie International Edition

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Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-09-08 , DOI: 10.1002/anie.202307288
Jianwu Tian ₁ , Bowen Li ₁ , Fu Zhang ₂ , Zhuo Yao ₂ , Wentao Song ₁ , Yufu Tang ₁ , Yuan Ping ₂ , Bin Liu ₁

Affiliation

Photodynamic therapy (PDT) is considered as one of the most momentous strategies to ablate cancer cells. However, the phototoxicity of photosensitizers pre and post PDT, and the tumor hypoxia environment, are the two major problems that limit the application of PDT. In this paper, we report an activatable type I photosensitizer TPFN-AzoCF₃, which could respond to cycling normoxia-hypoxia and undergo redox cycles in a fully reversible manner.

中文翻译：

光动力治疗前后具有淬灭光敏作用的可激活 I 型光敏剂

光动力疗法（PDT）被认为是消除癌细胞最重要的策略之一。然而，PDT前后光敏剂的光毒性以及肿瘤缺氧环境是限制PDT应用的两大问题。在本文中，我们报道了一种可激活的I型光敏剂TPFN-AzoCF ₃，它可以响应常氧-缺氧循环并以完全可逆的方式经历氧化还原循环。

更新日期：2023-09-08

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