Fluoroalkylation of Activated Allylic Acetates through Radical–Radical Coupling: Organophotoredox/DABCO Catalytic System,Organic Letters

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Fluoroalkylation of Activated Allylic Acetates through Radical–Radical Coupling: Organophotoredox/DABCO Catalytic System
Organic Letters ( IF 4.9 ) Pub Date : 2023-09-08 , DOI: 10.1021/acs.orglett.3c02456
Xiaoyu Zhang ₁ , Yinlei Zhang ₁ , Xiaohong Li ₁ , Bowen Li ₁ , Shiji Xiao ₂ , Yongming Tang ₁ , Peizhong Xie ₁ , Teck-Peng Loh _{1,

3,

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Affiliation

A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical–radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drugs, and amino acid derivatives to be incorporated into transformation. This study expands the synthetic toolbox for the construction of fluorine-containing molecules.

中文翻译：

通过自由基-自由基偶联活化烯丙乙酸酯的氟烷基化：有机光氧化还原/DABCO 催化系统

描述了一种新型有机光氧化还原/DABCO 催化系统，用于通过自由基-自由基偶联对活化的烯丙乙酸酯进行氟烷基化。该方法反应条件温和、选择性高、底物兼容性广泛，能够将多种生物活性分子、FDA批准的药物和氨基酸衍生物纳入转化。这项研究扩展了构建含氟分子的合成工具箱。

更新日期：2023-09-08

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