Ketyl Radical Coupling Enabled by Polycyclic Aromatic Hydrocarbon Electrophotocatalysts,Journal of the American Chemical Society

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Ketyl Radical Coupling Enabled by Polycyclic Aromatic Hydrocarbon Electrophotocatalysts
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-09-07 , DOI: 10.1021/jacs.3c06347
Joseph M Edgecomb ₁ , Sara N Alektiar ₁ , Nicholas G W Cowper ₁ , Jennifer A Sowin ₁ , Zachary K Wickens ₁

Affiliation

Herein, we report a new class of electrophotocatalysts, polycyclic aromatic hydrocarbons, that promote the reduction of unactivated carbonyl compounds to generate versatile ketyl radical intermediates. This catalytic platform enables previously challenging intermolecular ketyl radical coupling reactions, including those that classic reductants (e.g., SmI₂/HMPA) have failed to promote. More broadly, this study outlines an approach to fundamentally expand the array of reactive radical intermediates that can be generated via electrophotocatalysis by obviating the need for rapid mesolytic cleavage following substrate reduction.

中文翻译：

多环芳烃电光催化剂实现羰基偶联

在此，我们报告了一类新型电光催化剂，即多环芳烃，它可以促进未活化的羰基化合物的还原，生成多功能的羰基自由基中间体。该催化平台能够实现以前具有挑战性的分子间羰基自由基偶联反应，包括经典还原剂（例如SmI ₂ /HMPA）未能促进的反应。更广泛地说，这项研究概述了一种从根本上扩展可通过电光催化产生的反应性自由基中间体阵列的方法，通过消除底物还原后快速介观裂解的需要。

更新日期：2023-09-07

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