Non-steroidal Anti-inflammatory Drugs (NSAIDs) are extensively utilized pharmaceuticals worldwide. However, owing to the improper discharge and disposal practices, they have emerged as significant contaminants that are widely distributed in water, soils, and sewage sediments. This ubiquity poses a substantial threat to the ecosystem and human health. Consequently, it is imperative to develop rapid, cost-effective, efficient and reliable approaches for containing these substance in order to mitigate the deleterious impact of NSAIDs. This research provides a comprehensive review of the occurrence, fate, and hazards associated with NSAIDs in the general environment. Additionally, various removal technologies, including advanced oxidation processes, biodegradation, and adsorption, were systematically summarized. The study also presents a comparative analysis of the benefits and drawbacks of different removal technologies while interpreting challenges related to NSAIDs' removal and proposing strategies for future development.