Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties,ACS Applied Materials & Interfaces

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Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-09-06 , DOI: 10.1021/acsami.3c08525
Meiyan Wu ₁ , Pai Zhang ₂ , Mei Li ₃ , Rui Xu ₁ , Xin Zheng ₄ , Qiu Cui _{1,

5,

6} , Ruitao Cha ₂ , Bin Li _{1,

5,

6}

Affiliation

Surgical threads are of great importance to prevent wound infection and accelerate tissue healing in surgical treatment. Cellulose nanofibrils (CNF) and chitosan (CS) are attracting increasing attention to be employed as biomedicine materials due to their nontoxicity, cytocompatibility, and biodegradability. However, a robust and absorbable cellulose-based surgical thread has not been explored. Therefore, in this work, a bioinspired CNF/CS composite thread containing 5% cationic polyacrylamide (CPAM) by the mass of CS was prepared, and the obtained CNF/CS-5C thread exhibited excellent mechanical properties and low swelling ratio in water due to the high cross-link degree. Especially, the tensile strength (1877 ± 107 MPa) of this thread was much higher than that of most reported CNF-based threads. Meanwhile, compared with commercial silk and Vicryl surgical threads, the CNF/CS-5C thread exhibited better in vitro cytocompatibility toward endothelial and fibroblast cells and lower inflammatory response in vivo to subcutaneous tissues of rats. In addition, the obtained thread could be regarded as a promising absorbable suture, which exhibited excellent wound healing performances in vivo. Therefore, the prepared absorbable thread will open a new window to prepare novel and advanced cellulose-based threads for medical applications.

中文翻译：

仿生、坚固、可吸收的纤维素纳米纤维/壳聚糖丝，具有显着的细胞相容性和伤口愈合特性

手术线在外科治疗中对于预防伤口感染、加速组织愈合具有重要意义。纤维素纳米原纤维（CNF）和壳聚糖（CS）由于其无毒性、细胞相容性和生物可降解性而作为生物医学材料受到越来越多的关注。然而，尚未探索出坚固且可吸收的纤维素基手术线。因此，在本工作中，制备了一种仿生CNF/CS复合线，其含有按CS质量计5%的阳离子聚丙烯酰胺（CPAM），并且所得CNF/CS-5C线表现出优异的机械性能和在水中的低溶胀比。交联度高。特别是，该螺纹的拉伸强度（1877 ± 107 MPa）远高于大多数报道的基于 CNF 的螺纹。同时，与商业丝线和Vicryl手术线相比，CNF/CS-5C线对大鼠皮下组织表现出更好的体外细胞相容性和更低的体内炎症反应。此外，所获得的线可以被视为一种有前途的可吸收缝合线，在体内表现出优异的伤口愈合性能。因此，所制备的可吸收线将为制备用于医疗应用的新型和先进的纤维素基线打开一个新的窗口。

更新日期：2023-09-06

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