The aim of this study was to evaluate the association between obstructive sleep apnea and morning headache and to assess the improvement of morning headache following positive airway pressure therapy. One hundred and sixteen participants were enrolled in this study; all of them received positive airway pressure therapy for at least 3 months. We checked the differences in various sleep apnea-related parameters according to the presence of morning headache and evaluated the improvement of morning headache following positive airway pressure therapy. Among the 116 study participants, 103 were men, with a mean age and body mass index of 50.34 ± 10.23 years and 28.00 ± 4.21 kg/m², respectively. The severity of morning headache was higher in the severe obstructive sleep apnea group than in the mild to moderate group (2.16 ± 1.70 vs. 1.50 ± 1.57, P = 0.027). However, the various polysomnographic parameters did not significantly differ according to the presence of headache. The Epworth sleepiness scale score was significantly higher in the morning headache presence group than in the absence group (10.90 ± 5.45 vs. 8.13 ± 4.27, P = 0.003). Furthermore, a notable correlation was observed between the reduction in daytime sleepiness and the improvement in morning headache following PAP treatment (r = 0.503, P < 0.001). Morning headache significantly improved following positive airway pressure therapy (prevalence: 53.4–16.4%; severity: 1.92 ± 1.67 vs. 0.86 ± 0.80, all P < 0.001), especially in the patients with morning headache before positive airway pressure therapy. Morning headache is significantly associated with daytime sleepiness and positive airway pressure therapy improves morning headache.

本研究的目的是评估阻塞性睡眠呼吸暂停与早晨头痛之间的关联，并评估气道正压通气治疗后早晨头痛的改善情况。一百一十六名参与者参加了这项研究；他们都接受了至少3个月的气道正压通气治疗。我们根据早晨头痛的存在情况检查了各种睡眠呼吸暂停相关参数的差异，并评估了气道正压治疗后早晨头痛的改善情况。在 116 名研究参与者中，103 名是男性，平均年龄和体重指数分别为 50.34 ± 10.23 岁和 28.00 ± 4.21 kg/m ²。重度阻塞性睡眠呼吸暂停组早晨头痛的严重程度高于轻中度组（2.16±1.70比1.50±1.57，P  =0.027）。然而，根据头痛的存在，各种多导睡眠图参数没有显着差异。晨起头痛组的 Epworth 嗜睡量表评分显着高于无头痛组（10.90 ± 5.45 vs. 8.13 ± 4.27，P  = 0.003）。此外，PAP 治疗后白天嗜睡的减少与早晨头痛的改善之间观察到显着的相关性（r = 0.503，P  < 0.001）。气道正压通气治疗后早晨头痛显着改善（患病率：53.4–16.4%；严重程度：1.92 ± 1.67 vs. 0.86 ± 0.80，所有P  < 0.001），特别是在气道正压治疗前出现早晨头痛的患者中。早晨头痛与白天嗜睡显着相关，气道正压通气疗法可改善早晨头痛。