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A systematic analysis of residue and risk of cyantraniliprole in the water-sediment system: Does metabolism reduce its environmental risk?
Environment International ( IF 10.3 ) Pub Date : 2023-09-04 , DOI: 10.1016/j.envint.2023.108185 Saihong Yan 1 , Xiangyu Ren 2 , Lei Zheng 3 , Xiuguo Wang 2 , Tong Liu 2
Environment International ( IF 10.3 ) Pub Date : 2023-09-04 , DOI: 10.1016/j.envint.2023.108185 Saihong Yan 1 , Xiangyu Ren 2 , Lei Zheng 3 , Xiuguo Wang 2 , Tong Liu 2
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As a representative variety of diamide insecticides, cyantraniliprole has broad application prospects. In this study, the fate and risk of cyantraniliprole and its main metabolite J9Z38 in a water-sediment system were investigated. The present result showed that more J9Z38 was adsorbed in the sediment at the end of exposure. However, the bioaccumulation capacity of cyantraniliprole in zebrafish was higher than that of J9Z38. Cyantraniliprole had stronger influence on the antioxidant system and detoxification system of zebrafish than J9Z38. Moreover, cyantraniliprole induced more significant oxidative stress effect and more differentially expressed genes (DEGs) in zebrafish. Cyantraniliprole had significantly influence on the expression of RyR-receptor-related genes, which was confirmed by resolving their binding modes with key receptor proteins using AlphaFold2 and molecular docking techniques. In the sediment, both cyantraniliprole and J9Z38 had inhibitory effects on microbial community structure diversity and metabolic function, especially cyantraniliprole. The methane metabolism pathway, mediated by methanogens such as , , and may be the main pathway of degradation of cyantraniliprole and J9Z38 in sediments. The present results demonstrated that metabolism can reduce the environmental risk of cyantraniliprole in water-sediment system to a certain extent.
中文翻译：
水-沉积物系统中氰虫酰胺的残留和风险的系统分析：新陈代谢是否会降低其环境风险？
氰虫酰胺作为二酰胺类杀虫剂的代表品种，具有广阔的应用前景。在本研究中，调查了氰虫酰胺及其主要代谢物 J9Z38 在水-沉积物系统中的归宿和风险。目前的结果表明，在暴露结束时，沉积物中吸附了更多的 J9Z38。然而，氰虫酰胺在斑马鱼体内的生物富集能力高于J9Z38。氰虫酰胺对斑马鱼抗氧化系统和解毒系统的影响强于J9Z38。此外，氰虫酰胺在斑马鱼中诱导更显着的氧化应激效应和更多的差异表达基因（DEG）。 Cyantraniliprole 对 RyR 受体相关基因的表达有显着影响，这一点通过使用 AlphaFold2 和分子对接技术解析其与关键受体蛋白的结合模式得到证实。沉积物中，氰虫酰胺和J9Z38均对微生物群落结构多样性和代谢功能具有抑制作用，尤其是氰虫酰胺。由 、 、 等产甲烷菌介导的甲烷代谢途径可能是沉积物中氰虫酰胺和 J9Z38 降解的主要途径。本研究结果表明，代谢可以在一定程度上降低氰虫酰胺在水沙系统中的环境风险。
更新日期：2023-09-04
中文翻译：
水-沉积物系统中氰虫酰胺的残留和风险的系统分析：新陈代谢是否会降低其环境风险？
氰虫酰胺作为二酰胺类杀虫剂的代表品种，具有广阔的应用前景。在本研究中，调查了氰虫酰胺及其主要代谢物 J9Z38 在水-沉积物系统中的归宿和风险。目前的结果表明，在暴露结束时，沉积物中吸附了更多的 J9Z38。然而，氰虫酰胺在斑马鱼体内的生物富集能力高于J9Z38。氰虫酰胺对斑马鱼抗氧化系统和解毒系统的影响强于J9Z38。此外，氰虫酰胺在斑马鱼中诱导更显着的氧化应激效应和更多的差异表达基因（DEG）。 Cyantraniliprole 对 RyR 受体相关基因的表达有显着影响，这一点通过使用 AlphaFold2 和分子对接技术解析其与关键受体蛋白的结合模式得到证实。沉积物中，氰虫酰胺和J9Z38均对微生物群落结构多样性和代谢功能具有抑制作用，尤其是氰虫酰胺。由 、 、 等产甲烷菌介导的甲烷代谢途径可能是沉积物中氰虫酰胺和 J9Z38 降解的主要途径。本研究结果表明，代谢可以在一定程度上降低氰虫酰胺在水沙系统中的环境风险。
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