具有集成光热响应性的聚合物囊泡,Journal of the American Chemical Society

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具有集成光热响应性的聚合物囊泡
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-09-04 , DOI: 10.1021/jacs.3c07134
Yingtong Luo ₁ , Hanglong Wu ₁ , Xuan Zhou ₂ , Jianhong Wang ₁ , Süleyman Er ₂ , Yudong Li ₁ , Pascal L W Welzen ₁ , Roy A J F Oerlemans ₁ , Loai K E A Abdelmohsen ₁ , Jingxin Shao ₁ , Jan C M van Hest ₁

Affiliation

功能化聚合物囊泡因其良好的生物相容性、易于加工性和多功能响应能力而被证明在生物医学应用中具有广阔的前景。然而，由近红外（NIR）光触发的光热响应聚合物囊泡迄今为止尚未被广泛报道。在此，我们提出了一种设计近红外光介导的光热聚合物囊泡的新策略。通过将DD'-AD'-D构型框架与分子转子功能（TPE）相结合，合成了具有近红外触发光热特征的小分子（PTA）。通过密度泛函理论计算证明了该设计策略的可行性。在聚乙二醇-聚碳酸三亚甲基酯嵌段共聚物的疏水链段中引入PTA部分，其中碳酸酯单体在侧链上用活性酯基团进行改性。然后将两亲性嵌段共聚物（PEG ₄₄ -PTA ₂）用作光热响应聚合物囊泡自组装的构建单元。新型功能化聚合物囊泡继承了光热剂（PTA）的近红外介导的高光热性能。NIR激光照射10分钟后，PTA-Ps水溶液的温度升至56℃。激光照射后 PTA-P 的光热特性和双层结构仍然完好，这表明它们可以作为光热治疗的强大平台。除了光热性能外，还研究了 PTA-P 的负载能力。疏水性货物 (Cy7) 和亲水性货物 (Sulfo-Cy5) 成功封装在 PTA-P 中。这些特性使这类新型功能化聚合物囊泡成为抗癌治疗中协同治疗的有趣平台。

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Polymer Vesicles with Integrated Photothermal Responsiveness

Functionalized polymer vesicles have been proven to be highly promising in biomedical applications due to their good biocompatibility, easy processability, and multifunctional responsive capacities. However, photothermal-responsive polymer vesicles triggered by near-infrared (NIR) light have not been widely reported until now. Herein, we propose a new strategy for designing NIR light-mediated photothermal polymer vesicles. A small molecule (PTA) with NIR-triggered photothermal features was synthesized by combining a D-D′-A-D′-D configuration framework with a molecular rotor function (TPE). The feasibility of the design strategy was demonstrated through density functional theory calculations. PTA moieties were introduced in the hydrophobic segment of a poly(ethylene glycol)-poly(trimethylene carbonate) block copolymer, of which the carbonate monomers were modified in the side chain with an active ester group. The amphiphilic block copolymers (PEG₄₄-PTA₂) were then used as building blocks for the self-assembly of photothermal-responsive polymer vesicles. The new class of functionalized polymer vesicles inherited the NIR-mediated high photothermal performance of the photothermal agent (PTA). After NIR laser irradiation for 10 min, the temperature of the PTA-Ps aqueous solution was raised to 56 °C. The photothermal properties and bilayer structure of PTA-Ps after laser irradiation were still intact, which demonstrated that they could be applied as a robust platform in photothermal therapy. Besides their photothermal performance, the loading capacity of PTA-Ps was investigated as well. Hydrophobic cargo (Cy7) and hydrophilic cargo (Sulfo-Cy5) were successfully encapsulated in the PTA-Ps. These properties make this new class of functionalized polymer vesicles an interesting platform for synergistic therapy in anticancer treatment.

更新日期：2023-09-04

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