As sweat biomarker levels are continuously changing over metabolism and daily activities, pathological and physiological processes can be dynamically analyzed by wearable devices. The colorimetric skin-interfaced microfluidic devices that do not have external circuit modules exhibit enhanced deformability with a small footprint. However, it is difficult to achieve sampling over time and self-feedback for closed-loop systems. This review summarizes recent advances in microfluidic valves for biofluid management and chrono-sampling, as well as active triggers in microfluidics self-feedback. After enumerating the current limitations in temporal resolution and reliability, we further point out a few potential feasible strategies for future developments.

由于汗液生物标志物水平随着新陈代谢和日常活动而不断变化，因此可通过可穿戴设备动态分析病理和生理过程。没有外部电路模块的比色皮肤接口微流体装置表现出增强的可变形性和较小的占地面积。然而，闭环系统很难实现随时间采样和自反馈。本综述总结了用于生物流体管理和计时采样的微流体阀的最新进展，以及微流体自反馈的主动触发器。在列举了当前时间分辨率和可靠性方面的局限性之后，我们进一步指出了未来发展的一些潜在可行策略。