急性血液生物标志物谱可预测 COVID-19 住院后 6 个月和 12 个月的认知缺陷,Nature Medicine

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急性血液生物标志物谱可预测 COVID-19 住院后 6 个月和 12 个月的认知缺陷
Nature Medicine ( IF 58.7 ) Pub Date : 2023-08-31 , DOI: 10.1038/s41591-023-02525-y
Maxime Taquet _{1,

2} , Zuzanna Skorniewska ₁ , Adam Hampshire ₃ , James D Chalmers ₄ , Ling-Pei Ho ₅ , Alex Horsley _{6,

7} , Michael Marks _{8,

9,

10} , Krisnah Poinasamy ₁₁ , Betty Raman _{12,

13} , Olivia C Leavy _{14,

15} , Matthew Richardson ₁₅ , Omer Elneima ₁₅ , Hamish J C McAuley ₁₅ , Aarti Shikotra ₁₆ , Amisha Singapuri ₁₅ , Marco Sereno ₁₅ , Ruth M Saunders ₁₅ , Victoria C Harris _{15,

17} , Linzy Houchen-Wolloff _{18,

19,

20} , Neil J Greening ₁₅ , Parisa Mansoori ₂₁ , Ewen M Harrison ₂₂ , Annemarie B Docherty ₂₂ , Nazir I Lone _{23,

24} , Jennifer Quint ₂₅ , Naveed Sattar ₂₆ , Christopher E Brightling ₁₅ , Louise V Wain _{14,

15} , Rachael E Evans _{15,

17} , John R Geddes _{1,

2} , Paul J Harrison _{1,

2} ,

Affiliation

Department of Psychiatry, University of Oxford, Oxford, UK.
Oxford Health NHS Foundation Trust, Oxford, UK.
Department of Brain Sciences, Imperial College London, London, UK.
University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
MRC Human Immunology Unit, University of Oxford, Oxford, UK.
Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Manchester University NHS Foundation Trust, Manchester, UK.
Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Hospital for Tropical Diseases, University College London Hospital, London, UK.
Division of Infection and Immunity, University College London, London, UK.
Asthma and Lung UK, London, UK.
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Department of Population Health Sciences, University of Leicester, Leicester, UK.
The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
University Hospitals of Leicester NHS Trust, Leicester, UK.
Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Therapy Department, University Hospitals of Leicester, NHS Trust, Leicester, UK.
MQ: Transforming Mental Health, London, UK.
Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Usher Institute, University of Edinburgh, Edinburgh, UK.
Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK.
NHLI, Imperial College London, London, UK.
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.

新冠疫情后的认知缺陷，包括“脑雾”，在临床上很复杂，既有客观的成分，也有主观的成分。它们很常见并且使人衰弱，并且会影响工作能力，但它们的生物学基础仍然未知。在这项针对 1,837 名因 COVID-19 住院的成年人的前瞻性队列研究中，我们确定了在急性入院期间测量的两种不同的生物标志物谱，它们可以预测 COVID-19 后 6 个月和 12 个月的认知结果。第一个概况将相对于 C 反应蛋白升高的纤维蛋白原与客观和主观认知缺陷联系起来。第二个概况将相对于 C 反应蛋白升高的 D-二聚体与主观认知缺陷和职业影响联系起来。第二种情况是由疲劳和呼吸短促引起的。这两种情况都没有受到抑郁或焦虑的显着介导。二次分析结果稳健。在大规模电子健康记录数据集中对它们进行了复制，并测试了它们对 COVID-19 的特异性。这些发现为了解新冠病毒后认知缺陷的异质生物学提供了见解。

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更新日期：2023-09-01

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