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Stimuli-Actuated Turn-On Theranostic Nanoplatforms for Imaging-Guided Antibacterial Treatment
Small ( IF 13.0 ) Pub Date : 2023-08-30 , DOI: 10.1002/smll.202304127
Siyuan Yang 1 , Yingnan Song 1 , Heng Dong 2 , Yanling Hu 3 , Jingai Jiang 4 , Siyuan Chang 3 , Jinjun Shao 4 , Dongliang Yang 4
Small ( IF 13.0 ) Pub Date : 2023-08-30 , DOI: 10.1002/smll.202304127
Siyuan Yang 1 , Yingnan Song 1 , Heng Dong 2 , Yanling Hu 3 , Jingai Jiang 4 , Siyuan Chang 3 , Jinjun Shao 4 , Dongliang Yang 4
Affiliation
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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always-on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli-actuated turn-on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment-responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli-actuated turn-on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.
中文翻译：
用于成像引导抗菌治疗的刺激启动治疗诊断纳米平台
集诊断和治疗特性于一体的抗菌治疗纳米平台在精准医疗中展现出巨大的应用前景。然而，传统的治疗诊断纳米平台通常呈现始终在线的信号输出，这导致细菌感染治疗的特异性或选择性较差。为了应对这一挑战，开发了刺激驱动的开启纳米平台，用于同时激活诊断信号（例如荧光、光声、磁信号）和启动抗菌治疗。具体来说，通过将感染微环境响应性视觉信号激活和抗菌活性相结合，这些治疗诊断纳米平台可以发挥更高的准确诊断率和更有效的治疗效果。本文首先简要介绍临床常用的影像学和治疗策略。接下来，详细总结了刺激驱动的开启治疗诊断纳米平台治疗细菌感染性疾病的最新进展。最后，还概述和讨论了抗菌治疗纳米平台当前的瓶颈和未来的机遇。
更新日期：2023-08-30
中文翻译：
用于成像引导抗菌治疗的刺激启动治疗诊断纳米平台
集诊断和治疗特性于一体的抗菌治疗纳米平台在精准医疗中展现出巨大的应用前景。然而，传统的治疗诊断纳米平台通常呈现始终在线的信号输出，这导致细菌感染治疗的特异性或选择性较差。为了应对这一挑战，开发了刺激驱动的开启纳米平台，用于同时激活诊断信号（例如荧光、光声、磁信号）和启动抗菌治疗。具体来说，通过将感染微环境响应性视觉信号激活和抗菌活性相结合，这些治疗诊断纳米平台可以发挥更高的准确诊断率和更有效的治疗效果。本文首先简要介绍临床常用的影像学和治疗策略。接下来，详细总结了刺激驱动的开启治疗诊断纳米平台治疗细菌感染性疾病的最新进展。最后，还概述和讨论了抗菌治疗纳米平台当前的瓶颈和未来的机遇。
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