有缺陷的 S-TiO2−x/CeO2 异质结，用于相互增强化学动力学/声催化抗菌治疗和声电/离子激活骨再生,Advanced Functional Materials

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有缺陷的 S-TiO2−x/CeO2 异质结，用于相互增强化学动力学/声催化抗菌治疗和声电/离子激活骨再生
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-08-30 , DOI: 10.1002/adfm.202306493
Chaofeng Wang _{1,

2} , Jie Lei ₃ , Congyang Mao ₂ , Shuilin Wu _{2,

4,

5} , Yufeng Zheng ₄ , Chunyong Liang ₁ , Lei Yang ₁ , Shengli Zhu ₅ , Zhaoyang Li ₅ , Hui Jiang ₅ , Yu Zhang ₆ , Cao Yang ₃ , Xiangmei Liu _{1,

2}

Affiliation

声催化和化学动力学在抗菌治疗中引起了广泛关注。电子的传递效率在声催化和化学动力学中起着重要作用，如何调控电子传递并实现声催化和化学动力学之间的相互促进，以实现高效的抗菌治疗是一个难题。在这里，本研究开发了一种有缺陷的S掺杂TiO ₂和CeO ₂异质结（S-TiO ₂₋_x /CeO ₂）声敏剂，可以通过调节Ce ^III /Ce ^{IV的价态跃迁来增强化学动力学治疗}通过声电子，并通过创建异质结加速界面电子的转移来增强声催化治疗，从而实现声催化和化学动力学的相互增强。在超声波（US）照射下可杀死 99.3% 的金黄色葡萄球菌。由于CeO _{2中存在混合价态Ce}^III /Ce ^IV，S-TiO ₂₋_x /CeO ₂可以作为氧基质。Ce ⁴⁺可以消耗谷胱甘肽并与 H ₂ O _2反应在细菌中产生活性氧（ROS）。这些活性与声催化产生的 ROS 结合，导致细菌死亡。_{同时，S-TiO 2−}_x /CeO ₂在US刺激下产生的电信号和铈离子可以激活Wnt/β-catenin信号通路，诱导hBMSCs分化为成骨细胞。S-TiO ₂₋_x /CeO ₂在超声照射下成功治疗骨髓炎，有效清除感染、抑制炎症、促进骨再生，为深部感染患者提供有效治疗。

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Defective S-TiO2−x/CeO2 Heterojunction for Mutual Reinforcing Chemodynamic/Sonocatalytic Antibacterial Therapy and Sonoelectric/Ion-Activated Bone Regeneration

Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role in sonocatalysis and chemodynamics, and how to regulate electron transfer and achieve mutual-reinforcement between sonocatalysis and chemodynamic to achieve efficient antibacterial therapy is a difficult problem. Here, this study develops a defective S-doped TiO₂ and CeO₂ heterojunction(S-TiO₂₋_x/CeO₂）sonosensitizer that can enhance chemodynamic therapy by regulating valence transitions of Ce^III/Ce^IV by sonoelectrons, and enhancing sonocatalytic therapy by creating heterojunctions to accelerate the transfer of interface electron, thereby achieving mutual reinforcement of sonocatalysis and chemodynamic. It could kill 99.3% of S. aureus under ultrasound (US) irradiation . Due to the presence of mixed valence states Ce^III/Ce^IV in CeO₂, S-TiO₂₋_x/CeO₂ could be as oxy-substrates. Ce⁴⁺ can deplete glutathione and reacts with H₂O₂ in bacteria to produce reactive oxygen species (ROS). These activities combines with ROS generated from sonocatalysis, resulting in bacterial death. Meanwhile, the electrical signal generated by S-TiO₂₋_x/CeO₂ under US stimulation and the cerium ions could activate the Wnt/β-catenin signaling pathway to induce hBMSCs to differentiate into osteoblast. S-TiO₂₋_x/CeO₂ successfully treats osteomyelitis under US irradiation by effectively clearing infection, suppressing inflammatory, and promoting bone regeneration, and it provides effective treatment for patients with deep infection.

更新日期：2023-08-30

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