Abstract

Cancer accounts for ten million dies in each year. There are ample number of Food and Drug Administration (FDA) approved drugs for this disease. Due to severe side effects and multiple drug resistance, the current drug therapies become ineffective. So, the newer chemical moieties/entities with less toxic are necessary for the development. The nitrogen bearing heterocycle indole scaffold is considered one of the most privileged pharmacophores in heterocyclic compounds. New indole-based drug may serve as an effective for the development of new drug against this disease. This review amalgamates the current advances on indole based molecular frameworks and their unique anticancer relevance as reported over the last two decades. It highlights an inclination in the use of indole-based drug crafting and subsequent emergence of several potent drug against a range of cancer diseases in the clinical and pre-clinical stages of development.