用于牙周组织再生的 Janus 功能性电纺聚氨酯纤维膜,Journal of Materials Chemistry B

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用于牙周组织再生的 Janus 功能性电纺聚氨酯纤维膜
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-08-31 , DOI: 10.1039/d3tb01407j
Jingjing Lin ₁ , Yushui He ₁ , Yuanyuan He ₁ , Yuan Feng ₁ , Xiao Wang ₁ , Lei Yuan ₁ , Yanchao Wang _{1,

2} , Jie Chen ₃ , Feng Luo ₁ , Zhen Li ₁ , Jiehua Li ₁ , Hong Tan ₁

Affiliation

使用GTR膜的引导组织再生（GTR）技术是修复牙周缺损的有效方法。传统的牙周膜充当物理屏障，抵抗成纤维细胞、上皮细胞和结缔组织的生长。然而，它们不能促进牙周组织的再生。为了解决这个问题，根据治疗需求开发具有生物活性功能的新型 GTR 膜至关重要。在此，我们通过单轴静电纺丝开发了可生物降解的双层聚氨酯纤维膜，通过整合生物活性分子多巴胺（DA）和抗菌Gemini季铵盐（QAS）来构建具有Janus特性的两侧。含有DA的一侧位于损伤内部，可以有效促进细胞粘附和间充质干细胞生长，并支持矿化和抗氧化特性，这有利于骨再生。含有QAS的一侧位于损伤的外表面，具有抗菌特性，并且由于其强亲水性，限制了成纤维细胞在其表面的粘附和生长。体内研究表明Janus聚氨酯纤维膜可以显着促进大鼠牙周缺损的再生。由于其优异的机械性能和生物相容性，这种聚氨酯纤维膜在牙周再生领域具有潜在的应用前景。

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Janus functional electrospun polyurethane fibrous membranes for periodontal tissue regeneration

The guided tissue regeneration (GTR) technique with GTR membranes is an efficient method for repairing periodontal defects. Conventional periodontal membranes act as physical barriers that resist the growth of fibroblasts, epithelial cells, and connective tissue. However, they cannot facilitate the regeneration of periodontal tissue. To address this issue, the exploitation of novel GTR membranes with bioactive functions based on therapeutic requirements is critical. Herein, we exploited a biodegradable bilayer polyurethane fibrous membrane by uniaxial electrostatic spinning to construct two sides with Janus properties by integrating the bioactive molecule dopamine (DA) and antimicrobial Gemini quaternary ammonium salt (QAS). The DA-containing side, located inside the injury, can effectively promote cell adhesion and mesenchymal stem cell growth as well as support mineralization and antioxidant properties, which are beneficial for bone regeneration. The QAS-containing side, located on the outer surface of the injury, endows antibacterial properties and limits fibroblast adhesion and growth on its surface owing to its strong hydrophilicity. An in vivo study demonstrates that the Janus polyurethane fibrous membrane can significantly promote the regeneration of periodontal defects in rats. Owing to its superior mechanical properties and biocompatibility, this polyurethane fibrous membrane has potential applications in the field of periodontal regeneration.

更新日期：2023-08-31

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