Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**,ChemMedChem

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Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**
ChemMedChem ( IF 3.6 ) Pub Date : 2023-08-29 , DOI: 10.1002/cmdc.202300184
Marcela A Lopez-Sanchez ₁ , María Del Carmen Garcia-Rodriguez ₂ , Rodrigo Aguayo-Ortiz ₁ , Estefani Hernandez-Cruz ₂ , Diego I Figueroa-Figueroa ₁ , Francisco Hernandez-Luis ₁

Affiliation

One quinazolin-2,4,6-triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin-2,4,6-triamine derivatives acted as superoxide scavengers, and one 5,6-dihydro-3H-pirimidin-4-one showed bXO inhibitory activity.

中文翻译：

非嘌呤黄嘌呤氧化酶抑制剂喹唑啉-2,4,6-三胺衍生物的合成及其毒理学潜力的探索**

一种喹唑啉-2,4,6-三胺衍生物被发现是比别嘌呤醇更好的牛黄嘌呤氧化酶 (bXO) 抑制剂。三种喹唑啉衍生物在小鼠模型中不是微核诱导剂。三种喹唑啉-2,4,6-三胺衍生物充当超氧化物清除剂，一种5,6-二氢-3H-吡啶丁-4-酮表现出bXO抑制活性。

更新日期：2023-08-29

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