Considering the selective pharmacological activity and ecotoxicity of chiral drugs, the development of chiral materials with the dual functions of enantiomeric recognition and adsorption is of great significance. Herein, a novel bifunctional chiral composite (Fe₃O₄/CCDs@HP-ZIF-8) which does not contain expensive and rare fluorescent chiral ligands or metal ions, was constructed for the first time by encapsulating chiral carbon dots (CCDs) and magnetic Fe₃O₄ nanoparticles into hierarchical porous metal-organic frameworks (HP-MOFs). Fe₃O₄/CCDs@HP-ZIF-8, which integrates fluorescent chiral property, magnetism, and hierarchical porosity, shows enormous potential in enantiomeric recognition and adsorption. Fluorescence detection results demonstrate that Fe₃O₄/CCDs@HP-ZIF-8 presents different fluorescence quenching for naproxen enantiomers. The limits of detection are determined to be 0.05 μM for S-naproxen (S-Nap) and 0.30 μM for R-naproxen (R-Nap), respectively. Furthermore, the isothermal, kinetic, and thermodynamic adsorption behaviors of Fe₃O₄/CCDs@HP-ZIF-8 to naproxen enantiomers were systematically studied. Due to its hierarchical porosity, the composite exhibits higher adsorption capacity to naproxen enantiomers compared to the non-hierarchical porous composite. Studies of enantiomeric recognition and adsorption mechanisms affirm that the synergistic effect of multiple mechanisms exists between Fe₃O₄/CCDs@HP-ZIF-8 and naproxen enantiomers. Finally, the satisfactory recoveries and relative standard deviations in the actual sample assays demonstrate the practicality of Fe₃O₄/CCDs@HP-ZIF-8 for S-Nap detection. This non-destructive functionalization method creates an innovative pathway for developing advanced multifunctional chiral materials, holding great promise for enantiomeric recognition and adsorption.

考虑到手性药物的选择性药理活性和生态毒性，开发具有对映体识别和吸附双重功能的手性材料具有重要意义。在此，首次通过封装手性碳点（CCD）构建了一种不含昂贵且稀有的荧光手性配体或金属离子的新型双功能手性复合物（Fe 3 O 4 /CCDs@HP- ZIF _- 8 _）磁性 Fe ₃ O ₄纳米粒子进入分层多孔金属有机框架（HP-MOF）。Fe ₃ O ₄ /CCDs@HP-ZIF-8集荧光手性、磁性和分级孔隙性于一体，在对映体识别和吸附方面显示出巨大的潜力。荧光检测结果表明Fe ₃ O ₄ /CCDs@HP-ZIF-8对萘普生对映体表现出不同的荧光猝灭作用。S-萘普生 (S-Nap) 的检测限确定为 0.05 μM，R-萘普生 (R-Nap) 的检测限分别为 0.30 μM。_{此外，系统研究了Fe 3} O ₄ /CCDs@HP-ZIF-8对萘普生对映体的等温、动力学和热力学吸附行为。由于其分级孔隙率，与非分级多孔复合材料相比，该复合材料对萘普生对映体表现出更高的吸附能力。对映体识别和吸附机制的研究证实Fe ₃ O ₄ /CCDs@HP-ZIF-8与萘普生对映体之间存在多种机制的协同效应。_{最后，实际样品检测中令人满意的回收率和相对标准偏差证明了Fe 3} O ₄ /CCDs@HP-ZIF-8用于S-Nap检测的实用性。这种无损功能化方法为开发先进多功能手性材料开辟了一条创新途径，为对映体识别和吸附带来了巨大希望。