Sensitive detection and discrimination of multiple aminoglycosides (AGs) hold paramount importance in the efforts to curtail antibiotic overutilization and to monitor environmental impact. The present work provides a novel discriminative sensor ensemble based on a perylene derivative and SDS assemblies that can recognize nine different aminoglycosides. The fluorescent binary ensemble emits very weak fluorescence due to the strong aggregation of perylene-based probes in SDS pre-micelles. The addition of AGs can induce fast and remarkable fluorescence enhancement. The acquisition of fluorescence variation data at three characteristic emission wavelengths enables the generation of distinctive recognition pattern to each AG. Principal component analysis reveals that the sensor ensemble can correctly identify multiple AGs in both buffered aqueous solution and in 10% human urine. The fluorescence enhancement is attributed to the disaggregation of perylene units caused by the variation of SDS assembly from pre-micelle to micelles resulting from multi-point interaction with AGs. The strategy of modulation effect on fluorescence emission of encapsulated fluorophores by surfactant assemblies has been demonstrated to be highly effective for fabricating single system-based discriminative sensors for aminoglycosides.

S多种氨基糖苷类 (AG) 的灵敏检测和区分对于减少抗生素过度使用和监测环境影响至关重要。目前的工作提供了一种基于苝衍生物和 SDS 组件的新型判别式传感器整体，可以识别九种不同的氨基糖苷类。由于基于苝的探针在 SDS 预胶束中强烈聚集，荧光二元系综发出非常弱的荧光。AG的添加可以引起快速且显着的荧光增强。采集三个特征发射波长处的荧光变化数据能够为每个 AG 生成独特的识别模式。主成分分析表明，传感器整体可以正确识别缓冲水溶液和 10% 人尿中的多个 AG。荧光增强归因于与 AG 的多点相互作用导致 SDS 组装从前胶束到胶束的变化，导致苝单元解聚。表面活性剂组件对封装荧光团的荧光发射的调节效应已被证明对于制造基于单一系统的氨基糖苷类判别传感器非常有效。