在低成本、超便携设备上实现物理基质上合成大麻素的即时检测,Analytical Chemistry

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在低成本、超便携设备上实现物理基质上合成大麻素的即时检测
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-08-29 , DOI: 10.1021/acs.analchem.3c01844
Gyles E Cozier , Rachael C Andrews , Anca Frinculescu _{1,

2} , Ranjeet Kumar , Benedict May , Tom Tooth ₃ , Peter Collins ₄ , Andrew Costello _{5,

6} , Tom S F Haines , Tom P Freeman , Ian S Blagbrough , Jennifer Scott ₇ , Trevor Shine ₂ , Oliver B Sutcliffe ₅ , Stephen M Husbands , Jonathan Leach ₈ , Richard W Bowman ₉ , Christopher R Pudney ₁₀

Affiliation

Department of Analytical, Environmental and Forensic Sciences, King's College London, 150 Stamford Street, London SE1 9NH, U.K.
TICTAC Communications Ltd., Room 1.159 Jenner Wing, St. George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
HMP Bristol, 19 Cambridge Road, Horfield, Bristol BS7 8PS, U.K.
Avon and Somerset Police, Valley Road, Bristol BS20 8JJ, U.K.
MANchester DRug Analysis & Knowledge Exchange (MANDRAKE), Department of Natural Sciences, Manchester Metropolitan University, Manchester M1 5GD, U.K.
Greater Manchester Police, Openshaw Complex, Lawton Street, Openshaw, Manchester M11 2NS, U.K.
Centre for Academic Primary Care, Bristol Medical School, Bristol BS8 2PN, U.K.
Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, U.K.
School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, U.K.
Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, U.K.

合成大麻素 (SC) 是一类新型精神活性物质 (NPS)，主要用于英国的监狱和无家可归者社区。 SC 可能会产生严重的副作用，包括精神病、中风和癫痫发作，据报道有许多人因使用合成大麻素而死亡。。SC 的化学多样性对其检测提出了重大挑战，因为依赖特定分子识别的方法几乎立即就过时了。理想情况下，人们应该有一种通用方法来检测便携式环境中的 SC。SC 检测问题仍然更具挑战性，因为大多数 SC 进入监狱时都吸附在纸张、织物或草药材料等物理基质上。也就是说，无论使用何种检测方式，必要的提取步骤都会降低现场快速筛选材料的有效性和能力。在这里，我们展示了一种真正即时的 SC 通用测试，针对现实世界的药物缉获进行了测试。该测试基于两项进展。首先，我们在大多数物理基质的发射光谱中识别出光谱静音区域。其次，可以准确预测背景信号（包括来自自发荧光的信号）的发现是基于跟踪来自照射源的吸收光的部分。最后，我们证明可以利用大量物理底物的固有荧光来追踪其他感兴趣药物的存在，包括最新的苯二氮卓类药物和阿片类药物。我们演示了如何在便携式袖珍设备中实施我们的推定测试，该设备将立即在世界各地的监狱和执法机构中发挥作用。

"点击查看英文标题和摘要"

Instant Detection of Synthetic Cannabinoids on Physical Matrices, Implemented on a Low-Cost, Ultraportable Device

Synthetic cannabinoids (SCs) make up a class of novel psychoactive substances (NPS), used predominantly in prisons and homeless communities in the U.K. SCs can have severe side effects, including psychosis, stroke, and seizures, with numerous reported deaths associated with their use. The chemical diversity of SCs presents the major challenge to their detection since approaches relying on specific molecular recognition become outdated almost immediately. Ideally one would have a generic approach to detecting SCs in portable settings. The problem of SC detection is more challenging still because the majority of SCs enter the prison estate adsorbed onto physical matrices such as paper, fabric, or herb materials. That is, regardless of the detection modality used, the necessary extraction step reduces the effectiveness and ability to rapidly screen materials on-site. Herein, we demonstrate a truly instant generic test for SCs, tested against real-world drug seizures. The test is based on two advances. First, we identify a spectrally silent region in the emission spectrum of most physical matrices. Second, the finding that background signals (including from autofluorescence) can be accurately predicted is based on tracking the fraction of absorbed light from the irradiation source. Finally, we demonstrate that the intrinsic fluorescence of a large range of physical substrates can be leveraged to track the presence of other drugs of interest, including the most recent iterations of benzodiazepines and opioids. We demonstrate the implementation of our presumptive test in a portable, pocket-sized device that will find immediate utility in prisons and law enforcement agencies around the world.

更新日期：2023-08-29

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