Can acetate via FFA receptors contribute to the diabetogenic effect of statins?,Naunyn-Schmiedeberg's Archives of Pharmacology

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Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Naunyn-Schmiedeberg's Archives of Pharmacology ( IF 3.1 ) Pub Date : 2024-02-01 , DOI: 10.1007/s00210-023-02647-7
Finn Olav Levy ₁ , Jan-Bjørn Osnes ₁

Affiliation

Abstract

Despite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. The mechanism of this diabetogenic effect is unknown. We suggest a novel mechanism that may contribute to the diabetogenic effect of statins, through an effect of statins that has apparently escaped previous consideration. Briefly, by inhibiting HMG-CoA reductase, statins may cause accumulation of acetate, which through FFA2 and FFA3 stimulation may inhibit insulin secretion.

中文翻译：

醋酸盐能否通过 FFA 受体促进他汀类药物的糖尿病作用？

抽象的

尽管他汀类药物在预防心血管疾病方面已得到证实，但其引起糖尿病的作用却引起了人们的关注。这种致糖尿病作用的机制尚不清楚。我们提出了一种新的机制，可能通过他汀类药物的作用来促进他汀类药物的糖尿病作用，而这种作用显然没有被考虑到。简而言之，他汀类药物通过抑制 HMG-CoA 还原酶可能导致乙酸盐积聚，而乙酸盐通过刺激 FFA2 和 FFA3 可能抑制胰岛素分泌。

更新日期：2024-01-16

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