萝卜硫素在肝脏疾病中的治疗潜力：综述,Frontiers in Pharmacology

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萝卜硫素在肝脏疾病中的治疗潜力：综述
Frontiers in Pharmacology ( IF 4.4 ) Pub Date : 2023-08-29 , DOI: 10.3389/fphar.2023.1256029
Liang Yan ₁ , Yachun Yan ₁

Affiliation

过去几十年来，代谢相关脂肪肝和肝细胞癌等肝脏疾病的负担在全球范围内迅速增加。然而，针对这些肝脏疾病的药物治疗还不够。萝卜硫素（SFN）是一种主要存在于十字花科蔬菜中的异硫氰酸盐，已被发现具有广泛的活性，如抗氧化、抗炎、抗糖尿病和抗癌作用。近年来，越来越多的研究报道SFN可显着改善肝脏脂肪变性、预防脂肪肝的发生、提高胰岛素敏感性、减轻氧化损伤和肝损伤、诱导细胞凋亡、通过多种信号通路抑制肝癌细胞的增殖。而且，许多临床研究表明SFN对人体无害，并且个体耐受性良好。这一新的证据表明 SFN 是治疗肝病的有前途的候选药物。然而，由于 SFN 的特殊性质，包括不稳定性、水不溶性以及从西兰花芽提取物中使用时生物利用度的个体间差异大，SFN 作为保肝药物的开发存在局限性。本文全面综述SFN治疗常见肝病的最新进展及其机制，以期更好地了解SFN在肝病治疗中的潜力。

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Therapeutic potential of sulforaphane in liver diseases: a review

The burden of liver diseases such as metabolic-associated fatty liver diseases and hepatocellular carcinoma has increased rapidly worldwide over the past decades. However, pharmacological therapies for these liver diseases are insufficient. Sulforaphane (SFN), an isothiocyanate that is mainly found in cruciferous vegetables, has been found to have a broad spectrum of activities like antioxidation, anti-inflammation, anti-diabetic, and anticancer effects. Recently, a growing number of studies have reported that SFN could significantly ameliorate hepatic steatosis and prevent the development of fatty liver, improve insulin sensitivity, attenuate oxidative damage and liver injury, induce apoptosis, and inhibit the proliferation of hepatoma cells through multiple signaling pathways. Moreover, many clinical studies have demonstrated that SFN is harmless to the human body and well-tolerated by individuals. This emerging evidence suggests SFN to be a promising drug candidate in the treatment of liver diseases. Nevertheless, limitations exist in the development of SFN as a hepatoprotective drug due to its special properties, including instability, water insolubility, and high inter-individual variation of bioavailability when used from broccoli sprout extracts. Herein, we comprehensively review the recent progress of SFN in the treatment of common liver diseases and the underlying mechanisms, with the aim to provide a better understanding of the therapeutic potential of SFN in liver diseases.

更新日期：2023-08-29

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