Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

光动力疗法（PDT）作为下一代癌症治疗方法而备受关注，它可以选择性地破坏恶性组织，副作用较少，并且治疗过程中没有疼痛。最近开发了植入式PDT系统，以解决传统PDT系统笨重且昂贵的问题，并实施连续和重复的治疗。然而，现有的植入式PDT系统无法同时执行多种功能，例如调节光强度、测量和传输肿瘤相关数据，导致癌症治疗的复杂性。在这里，我们介绍了一种灵活且完全植入的无线光电系统，能够通过融合 PDT 和热疗并实时监测肿瘤大小来连续有效地治疗癌症。该系统采用微型无机发光二极管 (μ-LED)，发射波长为 624 nm 的光，旨在利用完全可编程的 μ-LED 光强度，并通过 Si 精确监测肿瘤大小，从而不会影响周围的正常组织。长期植入期间（2-3 周）的光电晶体管。通过体外实验、射线追踪模拟结果和体内肿瘤异种移植小鼠模型，证实了我们的系统通过无线电力和手机数据传输操作的同步癌症治疗和肿瘤大小监测能力的优越性。这种用于癌症治疗的一体化单一系统不仅可以有效治疗位于组织深处的肿瘤，还可以实时精确、连续地监测肿瘤大小。