<br>需要优先关注的典型有机磷酸盐二酯（di-OPE）综述：形成、发生、毒理学和流行病学研究,Journal of Hazardous Materials

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需要优先关注的典型有机磷酸盐二酯（di-OPE）综述：形成、发生、毒理学和流行病学研究
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2023-08-28 , DOI: 10.1016/j.jhazmat.2023.132426
Yi Peng ₁ , Chongli Shi ₁ , Chen Wang ₁ , Yu Li ₁ , Lingjun Zeng ₁ , Jin Zhang ₁ , Mengyan Huang ₁ , Yang Zheng ₁ , Haibo Chen ₁ , Chao Chen ₁ , Hui Li ₁

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有机磷酸盐三酯（tri-OPE）的初级代谢物，即有机磷酸酯二酯（di-OPE）对生态、环境和人类的影响不容忽视。虽然已经对 tri-OPEs 进行了广泛的研究，但关于 di-OPEs 的环境发生、毒性和健康风险的研究仍处于初步阶段。了解 di-OPEs 的当前研究现状对于指导未来对与环境有机磷酸酯（OPE）相关的生产、分销和风险的调查至关重要。本文具体综述了从 tri-OPEs 到 di-OPEs 的代谢过程以及 di-OPEs 在环境介质和生物体中的发生，提出了不同培养基中的典型 di-OPEs，并对其毒理学和流行病学发现进行了分类。通过综合分析，确定了 6 个 di-OPEs 为需要优先研究的典型 di-OPEs。这些包括磷酸二正丁酯（DNBP）、双（2-丁氧基乙基）磷酸酯（BBOEP）、双（1,3-二氯-2-丙基）磷酸酯（BDCIPP）、双（2-氯乙基）磷酸酯（BCEP）、双（1-氯-2-丙基）磷酸酯（BCIPP）和磷酸二苯酯（DPHP）。本文为后续对这些典型 di-OPEs 的毒理学研究提供了新的见解，旨在提高我们对它们现状的理解，并为 di-OPEs 的毒性和健康风险研究提供指导和思路。最终，本文旨在完善环境 OPE 的风险预警体系。

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Review on typical organophosphate diesters (di-OPEs) requiring priority attention: Formation, occurrence, toxicological, and epidemiological studies

The impact of primary metabolites of organophosphate triesters (tri-OPEs), namely, organophosphate diesters (di-OPEs), on the ecology, environment, and humans cannot be ignored. While extensive studies have been conducted on tri-OPEs, research on the environmental occurrence, toxicity, and health risks of di-OPEs is still in the preliminary stage. Understanding the current research status of di-OPEs is crucial for directing future investigations on the production, distribution, and risks associated with environmental organophosphate esters (OPEs). This paper specifically reviews the metabolization process from tri-OPEs to di-OPEs and the occurrence of di-OPEs in environmental media and organisms, proposes typical di-OPEs in different media, and classifies their toxicological and epidemiological findings. Through a comprehensive analysis, six di-OPEs were identified as typical di-OPEs that require prioritized research. These include di-n-butyl phosphate (DNBP), bis(2-butoxyethyl) phosphate (BBOEP), bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1-chloro-2-propyl) phosphate (BCIPP), and diphenyl phosphate (DPHP). This review provides new insights for subsequent toxicological studies on these typical di-OPEs, aiming to improve our understanding of their current status and provide guidance and ideas for research on the toxicity and health risks of di-OPEs. Ultimately, this review aims to enhance the risk warning system of environmental OPEs.

更新日期：2023-08-28

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