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Microenvironment-Responsive Hydrogels with Detachable Skin Adhesion and Mild-Temperature Photothermal Property for Chronic Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-08-27 , DOI: 10.1002/adfm.202305154 Huimin Geng 1, 2 , Xiaoyue Zheng 3 , Yulin Zhang 1 , Xiaomiao Cui 2 , Zhiwei Li 1 , Xunhui Zhang 2 , Jiwei Cui 2 , Fangang Meng 4 , Lei Sun 3 , Shilei Ni 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-08-27 , DOI: 10.1002/adfm.202305154 Huimin Geng 1, 2 , Xiaoyue Zheng 3 , Yulin Zhang 1 , Xiaomiao Cui 2 , Zhiwei Li 1 , Xunhui Zhang 2 , Jiwei Cui 2 , Fangang Meng 4 , Lei Sun 3 , Shilei Ni 1
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Chronic wounds have emerged as a global healthcare burden that have inability to heal within an expected time frame owing to the complex pathophysiological microenvironment, bacterial infection, multidrug resistance, and fragile skin tissue. Tailored to the features of chronic wounds, a multifunctional hydrogel (GA) composed of ethylenediamine-modified gelatin (Gela-amino) and oxidized sodium alginate (Alg─CHO) is reported. The thermosensitivity of gelatin and Schiff base bonds endow GA hydrogels with physiological temperature-enhanced nonirritating tissue adhesion and low-temperature-triggered nondestructive separation, beneficial for the management of vulnerable and sensitive wounds. In addition, GA hydrogels exhibit pH-responsive degradation that adapt to the acidic wound microenvironment. Under near-infrared (NIR) irradiation, DNase I enzyme and indocyanine green-loaded GA hydrogels (DI@GA) efficiently eradicate drug-resistant bacteria biofilm and subsequently exert an antibacterial effect attributed to the bioactity of GA hydrogels and mild-temperature photothermal therapy (≈45 °C). Remarkably, DI@GA/NIR hydrogels accelerate diabetic wound recovery and skin regeneration by dispersing biofilm, killing bacteria, inhibiting inflammation, promoting collagen deposition, and improving angiogenesis. The advanced hydrogels without the addition of antibiotics are promising to act as skin-friendly wound dressings for rescuing infectious and stalled chronic wounds.
中文翻译：
具有可拆卸皮肤粘附力和温和光热特性的微环境响应性水凝胶用于慢性伤口愈合
由于复杂的病理生理微环境、细菌感染、多重耐药性和脆弱的皮肤组织，慢性伤口无法在预期的时间内愈合，已成为全球医疗保健负担。针对慢性伤口的特点，报道了一种由乙二胺改性明胶（Gela-amino）和氧化海藻酸钠（Alg─CHO）组成的多功能水凝胶（GA）。明胶和希夫碱键的热敏感性赋予GA水凝胶生理温度增强的无刺激性组织粘附和低温触发的无损分离，有利于脆弱和敏感伤口的处理。此外，GA 水凝胶表现出 pH 响应性降解，可适应酸性伤口微环境。在近红外（NIR）照射下，DNase I酶和负载吲哚菁绿的GA水凝胶（DI@GA）有效消除耐药细菌生物膜，并随后通过GA水凝胶的生物活性和温和的温度光热疗法发挥抗菌作用（约 45 °C）。值得注意的是，DI@GA/NIR 水凝胶通过分散生物膜、杀死细菌、抑制炎症、促进胶原蛋白沉积和改善血管生成，加速糖尿病伤口恢复和皮肤再生。不添加抗生素的先进水凝胶有望成为皮肤友好的伤口敷料，用于拯救感染性和停滞的慢性伤口。
更新日期：2023-08-27
中文翻译：
具有可拆卸皮肤粘附力和温和光热特性的微环境响应性水凝胶用于慢性伤口愈合
由于复杂的病理生理微环境、细菌感染、多重耐药性和脆弱的皮肤组织，慢性伤口无法在预期的时间内愈合，已成为全球医疗保健负担。针对慢性伤口的特点，报道了一种由乙二胺改性明胶（Gela-amino）和氧化海藻酸钠（Alg─CHO）组成的多功能水凝胶（GA）。明胶和希夫碱键的热敏感性赋予GA水凝胶生理温度增强的无刺激性组织粘附和低温触发的无损分离，有利于脆弱和敏感伤口的处理。此外，GA 水凝胶表现出 pH 响应性降解，可适应酸性伤口微环境。在近红外（NIR）照射下，DNase I酶和负载吲哚菁绿的GA水凝胶（DI@GA）有效消除耐药细菌生物膜，并随后通过GA水凝胶的生物活性和温和的温度光热疗法发挥抗菌作用（约 45 °C）。值得注意的是，DI@GA/NIR 水凝胶通过分散生物膜、杀死细菌、抑制炎症、促进胶原蛋白沉积和改善血管生成，加速糖尿病伤口恢复和皮肤再生。不添加抗生素的先进水凝胶有望成为皮肤友好的伤口敷料，用于拯救感染性和停滞的慢性伤口。
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