Abstract

Alginates varying in modifying additives (primarily, chitosan) and physical treatment methods are used to design prototypes of innovative wound dressings. The aims of the study were to create a prototype sodium alginate fabric wound dressing with silver nanoparticles (AgNPs) subjected to ten freeze–thaw cycles, to assess its properties, and to evaluate its efficacy in treating the purulent wound process in rats. The original technology of ten freeze–thaw cycles was shown to significantly increase the AgNP amount in the sodium alginate wound dressing, primarily by increasing the amount of AgNPs no larger than 15 nm in diameter, which exert the highest antibacterial activity. The wound dressing with AgNPs reduced the metabolic disturbances in the local function of the nonspecific defense system. On days 3 and 5 after wounding, free radical oxidation indices were more favorable and the levels of antioxidant enzymes (catalase and superoxide dismutase (SOD)) in wound tissue were lower than observed upon application of a wound dressing with AgNPs, but without alginate, or after daily wound debridement without using alginate or AgNPs.

中文翻译：

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含银纳米粒子的海藻酸盐织物敷料对实验动物伤口过程的影响

摘要

使用不同的改性添加剂（主要是壳聚糖）和物理处理方法的藻酸盐来设计创新伤口敷料的原型。该研究的目的是创建一种含有银纳米颗粒（AgNP）的海藻酸钠织物伤口敷料原型，并进行十次冻融循环，以评估其特性，并评估其治疗大鼠化脓性伤口过程的功效。原创技术的十次冻融循环显着增加了海藻酸钠伤口敷料中纳米银的含量，主要是通过增加直径不大于15纳米的纳米银的含量，从而发挥最高的抗菌活性。含有AgNPs的伤口敷料减少了非特异性防御​​系统局部功能的代谢紊乱。受伤后第 3 天和第 5 天，