Development of a Cyanide-free and Scalable Route for the ADAMTS-5 Inhibitor GLPG1972: Synthesis of an Advanced Key Chiral Intermediate,ChemistrySelect

当前位置： X-MOL 学术 › ChemistrySelect › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Development of a Cyanide-free and Scalable Route for the ADAMTS-5 Inhibitor GLPG1972: Synthesis of an Advanced Key Chiral Intermediate
ChemistrySelect ( IF 1.9 ) Pub Date : 2023-08-24 , DOI: 10.1002/slct.202301762
Charan Kumar G _{1,

2} , Anusooya S ₁ , Gaikwad Rajendra _{1,

2} , Krithika Ganesh ₁ , Ramaraj Selvaraj _{1,

2} , Govinda Rajulu G ₁ , Ganesh Sambasivam ₁ , C S Karthik ₂

Affiliation

A mild, efficient, scalable, cyanide-free and environmentally-benign procedure has been demonstrated for the synthesis of 5,5-disubstituted hydantoins starting from alkylnitriles and diethyl carbonate.

中文翻译：