Virus-Based Pyroelectricity,Advanced Materials

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Virus-Based Pyroelectricity
Advanced Materials ( IF 27.4 ) Pub Date : 2023-08-23 , DOI: 10.1002/adma.202305503
Han Kim _{1,

2} , Kento Okada _{3,

4} , Inseok Chae _{2,

3} , Butaek Lim _{2,

3} , Seungwook Ji _{1,

2} , Yoonji Kwon ₃ , Seung-Wuk Lee _{1,

2,

3}

Affiliation

The first observation of heat-induced electrical potential generation on a virus and its detection through pyroelectricity are presented. Specifically, the authors investigate the pyroelectric properties of the M13 phage, which possesses inherent dipole structures derived from the noncentrosymmetric arrangement of the major coat protein (pVIII) with an α-helical conformation. Unidirectional polarization of the phage is achieved through genetic engineering of the tail protein (pIII) and template-assisted self-assembly techniques. By modifying the pVIII proteins with varying numbers of glutamate residues, the structure-dependent tunable pyroelectric properties of the phage are explored. The most polarized phage exhibits a pyroelectric coefficient of 0.13 µC m⁻² °C⁻¹. Computational modeling and circular dichroism (CD) spectroscopy analysis confirm that the unfolding of α-helices within the pVIII proteins leads to changes in phage polarization upon heating. Moreover, the phage is genetically modified to enable its pyroelectric function in diverse chemical environments. This phage-based approach not only provides valuable insights into bio-pyroelectricity but also opens up new opportunities for the detection of various viral particles. Furthermore, it holds great potential for the development of novel biomaterials for future applications in biosensors and bioelectric materials.

中文翻译：

基于病毒的热释电

首次观察到病毒上热诱导电势的产生及其通过热释电的检测。具体而言，作者研究了 M13 噬菌体的热释电特性，该噬菌体具有源自具有 α 螺旋构象的主要外壳蛋白 (pVIII) 非中心对称排列的固有偶极结构。噬菌体的单向极化是通过尾部蛋白 (pIII) 的基因工程和模板辅助自组装技术实现的。通过用不同数量的谷氨酸残基修饰 pVIII 蛋白，探索了噬菌体的结构依赖性可调热释电特性。^{最极化的噬菌体表现出0.13 µC m -2} °C ^-1的热电系数。计算模型和圆二色性 (CD) 光谱分析证实，pVIII 蛋白内 α 螺旋的展开会导致加热时噬菌体极化的变化。此外，噬菌体经过基因改造，使其能够在不同的化学环境中发挥热电功能。这种基于噬菌体的方法不仅为生物热电提供了宝贵的见解，而且为检测各种病毒颗粒开辟了新的机会。此外，它在开发新型生物材料以用于生物传感器和生物电材料的未来应用方面具有巨大的潜力。

更新日期：2023-08-23

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