A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-08-24 , DOI: 10.1021/acsami.3c05412
Lihua Li _{1,

2} , Zefeng Lin _{3,

4} , Xingyi Xu ₃ , Wanshun Wang ₄ , Hu Chen ₄ , Zhibin Feng ₄ , Zhongmin Yang ₅ , Jianhua Hao ₂

Affiliation

Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth–manganese core–shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO_x, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnO_x nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO_x nanozymes have also been systematically studied and revealed.

中文翻译：

用于肿瘤级联放大饥饿和化学动力学治疗的 pH/GSH/葡萄糖响应纳米酶

纳米酶为疾病治疗学带来了巨大的机遇。在这里，一种基于含有葡萄糖氧化物（GOx）的铋锰核壳纳米花的自增强催化纳米晶体，称为BDS-GOx@MnO x ，被设计用于体外和_体内4T1肿瘤治疗诊断。BDS-GOx@MnO _x纳米酶能够高效增强饥饿治疗 (ST) 和化疗 (CDT)，并对肿瘤治疗以及肿瘤增强计算机断层扫描 (CT) 和磁学表现出敏感的肿瘤微环境 (TME) 响应特性。磁共振 (MR) 诊断成像。_{BDS-GOx@MnO x}纳米酶的特性和机理也得到了系统的研究和揭示。

更新日期：2023-08-24

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南