Naringenin (4′,5,7-trihydroxyflavonone) is a phytochemical mainly found in citrus fruits. It is a promising phytochemical for human health because of its beneficial effects. This review aims to present comprehensive information on naringenin biological activities along with its action mechanisms and explain the pharmacokinetic properties of naringenin. This study involves a comprehensive literature review of in vitro and in vivo studies examining the effects of naringenin. Naringenin has antidiabetic, anticancer, antimicrobial, antiobesity, gastroprotective, immunomodulator, cardioprotective, nephroprotective, and neuroprotective properties. These properties are primarily attributed to its antioxidant and anti-inflammatory activities. The most important antioxidant activities of naringenin including free radical scavenging and preventing lipid peroxidation. Naringenin can increase the concentration of antioxidant enzymes and inhibit metal chelation and various pro-oxidant enzymes. Anti-inflammatory activities of naringenin are associated with decreased mitogen-activated protein kinase activities and nuclear factor kappa B by modulating the expression and release of proinflammatory cytokine and enzymes. In vitro and in vivo studies show that naringenin has promising biological activities for a variety of diseases. More research must be conducted on the bioactivities of naringenin, and to determine its optimum dose. In addition, the efficiency of naringenin must be examined with enhanced bioavailability methods to be able to increase its therapeutic effect.

柚皮素（4',5,7-三羟基黄酮）是一种主要存在于柑橘类水果中的植物化学物质。由于其有益作用，它是一种对人类健康有前途的植物化学物质。本综述旨在提供有关柚皮素生物活性及其作用机制的全面信息，并解释柚皮素的药代动力学特性。这项研究涉及对柚皮素作用的体外和体内研究的全面文献综述。柚皮素具有抗糖尿病、抗癌、抗菌、抗肥胖、胃保护、免疫调节、心脏保护、肾保护和神经保护特性。这些特性主要归因于其抗氧化和抗炎活性。柚皮素最重要的抗氧化活性包括清除自由基和防止脂质过氧化。柚皮素可以增加抗氧化酶的浓度并抑制金属螯合和各种促氧化酶。柚皮素的抗炎活性通过调节促炎细胞因子和酶的表达和释放，与丝裂原激活蛋白激酶活性和核因子 kappa B的降低有关。体外和体内研究表明柚皮素对多种疾病具有良好的生物活性。必须对柚皮素的生物活性进行更多的研究，并确定其最佳剂量。此外，必须通过增强生物利用度的方法来检查柚皮素的效率，以提高其治疗效果。