<br>脂质体-温敏水凝胶系统的透皮缓释特性及抗光老化功效,Advanced Healthcare Materials

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脂质体-温敏水凝胶系统的透皮缓释特性及抗光老化功效
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-08-22 , DOI: 10.1002/adhm.202301933
Sijie Wu ₁ , Gaodan Liu ₁ , Ping Shao _{1,

2} , Xingyu Lin ₃ , Jiahao Yu _{1,

2} , Hanchi Chen ₄ , Huiliang Li ₅ , Simin Feng _{1,

2}

Affiliation

药物输送系统已成为生物医学领域的研究重点。将脂质体掺入水凝胶进一步形成更强大的多功能系统，以实现更有效和持续的局部药物递送。在这项研究中，开发了羧甲基修饰的壳聚糖/透明质酸（CMC/HA、CMH）热敏水凝胶，用于脂质体的持续透皮递送。水凝胶通过氢键、疏水相互作用和静电相互作用交联。凝胶性质可以通过取代度（DS）来调节，当DS=18.20±0.67%（CMH2）时，凝胶温度为37.8℃，可以在体温下快速凝胶化（315s）。此外，CMH2水凝胶具有合适的铺展性（17.7-57.2 cm ² ）、粘度（2133.4 mPa s）和多孔结构，有利于其在皮肤上的粘附和应用以及脂质体递送。水凝胶可以延迟脂质体的释放，24小时内抗坏血酸葡萄糖苷(AA2G)的释放率为33.92-49.35%。水凝胶避免了脂质体从皮肤上的快速清除，提高了皮肤的保留性，实现了生物活性成分的长期释放。脂质体-水凝胶系统更有效地促进AA2G对皮肤的抗光老化作用，减少表皮厚度、黑色素沉积和脂质氧化损伤，并增加胶原蛋白密度。因此，脂质体-水凝胶系统被建议作为持续透皮递送的多功能递送系统。

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Transdermal Sustained Release Properties and Anti-Photoaging Efficacy of Liposome-Thermosensitive Hydrogel System

Drug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional systems for more effective and sustained topical drug delivery. In this study, carboxymethyl-modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed for sustained transdermal delivery of liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction and electrostatic interaction. The gel properties can be regulated by substitution degree (DS), and when DS = 18.20 ± 0.67% (CMH2), the gel temperature is 37.8 °C, allowing rapid gelation at body temperature (315 s). Moreover, CMH2 hydrogel has suitable spreadability (17.7–57.2 cm²), viscosity (2133.4 mPa s) and porous structure, which facilitated its adhesion and application on the skin and liposomes delivery. The hydrogel can retard the liposomes release, and the release rate of ascorbyl glucoside (AA2G) is 33.92–49.35% in 24 h. Hydrogel avoids the rapid clearance of liposomes from the skin and improved the skin retention, achieving the long-term release of bioactive components. Liposome-hydrogel system more efficiently promotes the anti-photoaging effect of AA2G on skin, reducing epidermal thickness, melanin deposition and lipid oxidative damage and increasing collagen density. Therefore, liposome-hydrogel systems are proposed as multifunctional delivery systems for sustained transdermal delivery.

更新日期：2023-08-22

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