Continuous monitoring of arterial blood pressure (BP) outside of a clinical setting is crucial for preventing and diagnosing hypertension related diseases. However, current continuous BP monitoring instruments suffer from either bulky systems or poor user-device interfacial performance, hampering their applications in continuous BP monitoring. Here, we report a thin, soft, miniaturized system (TSMS) that combines a conformal piezoelectric sensor array, an active pressure adaptation unit, a signal processing module, and an advanced machine learning method, to allow real wearable, continuous wireless monitoring of ambulatory artery BP. By optimizing the materials selection, control/sampling strategy, and system integration, the TSMS exhibits improved interfacial performance while maintaining Grade A level measurement accuracy. Initial trials on 87 volunteers and clinical tracking of two hypertension individuals prove the capability of the TSMS as a reliable BP measurement product, and its feasibility and practical usability in precise BP control and personalized diagnosis schemes development.

在临床环境之外持续监测动脉血压（BP）对于预防和诊断高血压相关疾病至关重要。然而，当前的连续血压监测仪器要么系统庞大，要么用户设备界面性能较差，阻碍了其在连续血压监测中的应用。在这里，我们报告了一种薄的、柔软的小型化系统（TSMS），它结合了保形压电传感器阵列、主动压力适应单元、信号处理模块和先进的机器学习方法，可以实现真正的可穿戴、连续无线动态监测动脉血压。通过优化材料选择、控制/采样策略和系统集成，TSMS 表现出改进的界面性能，同时保持 A 级测量精度。对87名志愿者的初步试验和对两名高血压患者的临床跟踪证明了TSMS作为可靠血压测量产品的能力，及其在精确血压控制和个性化诊断方案开发方面的可行性和实用性。