点击水凝胶传递聚集诱导的发射纳米囊泡，用于深度烧伤伤口的同时重塑和抗菌,Aggregate

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点击水凝胶传递聚集诱导的发射纳米囊泡，用于深度烧伤伤口的同时重塑和抗菌
Aggregate ( IF 13.9 ) Pub Date : 2023-08-17 , DOI: 10.1002/agt2.406
Xu Chen ₁ , Meijiao Zhao ₂ , Qihu Xie ₃ , Sitong Zhou ₄ , Xiaoping Zhong ₃ , Judun Zheng ₂ , Ronghua Yang ₅ , Xianjin Du ₆ , Jinyu Xia ₁ , Yuhui Liao ₂

Affiliation

作为一种高危创伤，深度烧伤的修复过程总是因组织再生能力下降和持续感染而受到阻碍。在这项研究中，我们开发了一种同时治疗深度烧伤伤口的策略，使用具有抗菌和组织重塑特性的功能性纳米囊泡，通过点击化学水凝胶传递。4-(2-(5-(4-(二苯氨基)苯基)噻吩-2-基)乙烯基)-1-(2-羟乙基)吡啶-1-溴化鎓(THB)的聚集诱导发射光敏剂，具有优异的首先制备具有光动力学特性的材料，然后与容易获得的脂肪干细胞衍生的纳米囊泡相结合，生成 THB 功能化纳米囊泡（THB@ANV）。THB@ANVs 对革兰氏阳性菌表现出很强的抗菌活性（杀灭率高达 100%），并且对组织重塑也有有益作用，包括促进细胞迁移、细胞增殖和调节免疫。此外，我们还制备了羧甲基壳聚糖的点击水凝胶，用于在伤口上有效递送 THB@ANV。这种水凝胶可以被注射以符合伤口形态，同时响应酸性微环境。伤口愈合的体内评估表明，THB@ANVs水凝胶敷料通过减少细菌生长、调节炎症、促进早期血管生成和胶原蛋白沉积，有效加速二度烧伤伤口的愈合。这项研究为深度烧伤创面修复提供了具有多种功能的伤口敷料的有前途的候选材料。

"点击查看英文标题和摘要"

Click-hydrogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds

As a high-risk trauma, deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent infections. In this study, we developed a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties, delivered via a click-chemistry hydrogel. An aggregation-induced emission photosensitizer of 4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1-(2-hydroxyethyl) pyridin-1-ium bromide (THB) with excellent photodynamic properties was first prepared, and then combined with readily accessible adipose stem cells-derived nanovesicles to generate the THB functionalized nanovesicles (THB@ANVs). The THB@ANVs showed strong antibacterial activity against Gram-positive bacteria (up to 100% killing rate), and also beneficial effects on tissue remodeling, including promoting cell migration, cell proliferation, and regulating immunity. In addition, we prepared a click-hydrogel of carboxymethyl chitosan for effective delivery of THB@ANVs on wounds. This hydrogel could be injected to conform to the wound morphology while responding to the acidic microenvironment. In vivo evaluations of wound healing revealed that the THB@ANVs hydrogel dressing efficiently accelerated the healing of second-degree burn wounds by reducing bacterial growth, regulating inflammation, promoting early angiogenesis, and collagen deposition. This study provides a promising candidate of wound dressing with diverse functions for deep burn wound repair.

更新日期：2023-08-17

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