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Bone tissue engineering application of 3-aminopropyltrimethoxysilane functionalized Au/Ag bimetallic nanoparticles incorporated hydroxyapatite bioceramic
Journal of Materials Research ( IF 2.7 ) Pub Date : 2023-08-17 , DOI: 10.1557/s43578-023-01132-4
Maneesha Pandey , Alok Singh Verma , P. C. Pandey , Roger J. Narayan

Despite having excellent osteoconductivity and biocompatibility, hydroxyapatite (HA) exhibits inadequate mechanical properties and bacterial susceptibility, which limits its medical applications. The present study aims to fabricate 3-aminopropyltrimethoxysilane (3-APTMS) functionalized gold (Au)-silver (Ag) nanoparticles incorporated in hydroxyapatite bioceramics to overcome this limitation. Thermogravimetric analysis (TGA), X-Ray diffraction, and scanning electron microscopy were carried out to understand the physical and chemical characteristics of the material. The maximum values of fracture toughness, hardness, compressive and flexural strength were measured for HA-10 Au/Ag NPs. Both quantitative and qualitative analyses of antibacterial behavior revealed that the adhesion of gram-positive (Staphylococcu aureus) and gram-negative (Eschericia coli) bacterial cells were reduced significantly after the incorporation of Au/Ag NPs as compared with the HA control. In addition, the effect of Au/Ag NPs incorporation on the cellular response was observed for the MG63 cell line. Both the quantitative and qualitative results indicate significantly enhanced cell proliferation with the incorporation of Au/Ag NPs as compared to HA. The addition of Au/Ag NPs in HA provides a material with appropriate mechanical, antibacterial, and cellular responses for further consideration.

Graphical abstract



中文翻译:

3-氨丙基三甲氧基硅烷功能化Au/Ag双金属纳米粒子掺入羟基磷灰石生物陶瓷的骨组织工程应用

尽管羟基磷灰石(HA)具有优异的骨传导性和生物相容性,但其机械性能和细菌敏感性不足,限制了其医疗应用。本研究旨在制造掺入羟基磷灰石生物陶瓷中的 3-氨基丙基三甲氧基硅烷 (3-APTMS) 功能化金 (Au)-银 (Ag) 纳米粒子,以克服这一限制。通过热重分析 (TGA)、X 射线衍射和扫描电子显微镜来了解材料的物理和化学特性。测量了 HA-10 Au/Ag NP 的断裂韧性、硬度、压缩强度和弯曲强度的最大值。抗菌行为的定量和定性分析表明,革兰氏阳性菌(金黄色葡萄球菌)的粘附与 HA 对照相比,掺入 Au/Ag NP 后,革兰氏阴性(大肠杆菌)细菌细胞显着减少。此外,还观察到 Au/Ag NP 掺入对 MG63 细胞系细胞反应的影响。定量和定性结果均表明,与 HA 相比,Au/Ag NP 的掺入显着增强了细胞增殖。在 HA 中添加 Au/Ag NP 可提供具有适当机械、抗菌和细胞反应的材料,供进一步考虑。

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更新日期:2023-08-17
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