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Peptide Hydrogels and Nanostructures Controlling Biological Machinery
Langmuir ( IF 3.7 ) Pub Date : 2023-08-17 , DOI: 10.1021/acs.langmuir.3c01269
Jovana Mitrovic 1 , Gabriella Richey 1 , Sarah Kim 1 , Mustafa O Guler 1
Affiliation  

Peptides are versatile building blocks for the fabrication of various nanostructures that result in the formation of hydrogels and nanoparticles. Precise chemical functionalization promotes discrete structure formation, causing controlled bioactivity and physical properties for functional materials development. The conjugation of small molecules on amino acid side chains determines their intermolecular interactions in addition to their intrinsic peptide characteristics. Molecular information affects the peptide structure, formation, and activity. In this Perspective, peptide building blocks, nanostructure formation mechanisms, and the properties of these peptide materials are discussed with the results of recent publications. Bioinstructive and stimuli-responsive peptide materials have immense impacts on the nanomedicine field including drug delivery, cellular engineering, regenerative medicine, and biomedicine.

中文翻译:

控制生物机械的肽水凝胶和纳米结构

肽是用于制造各种纳米结构的多功能构建块,从而形成水凝胶和纳米颗粒。精确的化学功能化促进离散结构的形成,从而为功能材料的开发提供受控的生物活性和物理特性。小分子在氨基酸侧链上的缀合除了决定其内在的肽特性外,还决定了它们的分子间相互作用。分子信息影响肽的结构、形成和活性。在本视角中,肽构建模块、纳米结构形成机制以及这些肽材料的特性与最近出版物的结果进行了讨论。生物指导和刺激响应肽材料对纳米医学领域具有巨大影响,包括药物输送、细胞工程、再生医学和生物医学。
更新日期:2023-08-17
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