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S-alkyl Dithiocarbamates Synthesis through Electrochemical Multicomponent Reaction of Thiols, Hydrogen Sulfide, and Isocyanides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-08-16 , DOI: 10.1021/acs.joc.3c01017
Xiaoying Liu 1 , Tian-Cheng Cai 1 , Mengxue Zhu 1 , Yuxuan Liu 1 , Jingjing Xia 1 , Junyan Xie 2 , Lixin Wen 3 , Qing-Wen Gui 1 , Yulong Yin 2
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-08-16 , DOI: 10.1021/acs.joc.3c01017
Xiaoying Liu 1 , Tian-Cheng Cai 1 , Mengxue Zhu 1 , Yuxuan Liu 1 , Jingjing Xia 1 , Junyan Xie 2 , Lixin Wen 3 , Qing-Wen Gui 1 , Yulong Yin 2
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Dithiocarbamates synthesis is extremely important in plenty of biomedical and agrochemical applications, especially fungicide development, but remains a great challenge. In this work, we have successfully developed a multicomponent reaction protocol to convert H2S into S-alkyl dithiocarbamates under constant current conditions. No additional oxidants nor additional catalysts are required, and due to mild conditions, the reactions display a broad substrate scope, including varieties of thiols or disulfides.
中文翻译:
硫醇、硫化氢和异氰化物电化学多组分反应合成二硫代氨基甲酸S-烷基酯
二硫代氨基甲酸盐的合成在许多生物医学和农业化学应用中极其重要,特别是杀菌剂的开发,但仍然是一个巨大的挑战。在这项工作中,我们成功开发了一种多组分反应方案,可在恒流条件下将H 2 S转化为S-烷基二硫代氨基甲酸酯。不需要额外的氧化剂或额外的催化剂,并且由于条件温和,反应显示出广泛的底物范围,包括各种硫醇或二硫化物。
更新日期:2023-08-16
中文翻译:
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硫醇、硫化氢和异氰化物电化学多组分反应合成二硫代氨基甲酸S-烷基酯
二硫代氨基甲酸盐的合成在许多生物医学和农业化学应用中极其重要,特别是杀菌剂的开发,但仍然是一个巨大的挑战。在这项工作中,我们成功开发了一种多组分反应方案,可在恒流条件下将H 2 S转化为S-烷基二硫代氨基甲酸酯。不需要额外的氧化剂或额外的催化剂,并且由于条件温和,反应显示出广泛的底物范围,包括各种硫醇或二硫化物。