Visible-Light-Mediated Synthesis of α-Aryl Ester Derivatives via an EDA Complex,The Journal of Organic Chemistry

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Visible-Light-Mediated Synthesis of α-Aryl Ester Derivatives via an EDA Complex
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-08-16 , DOI: 10.1021/acs.joc.3c01201
Yutong Liu ₁ , Shuangqiao Li ₁ , Xueqin Chen ₁ , Hezhong Jiang ₁

Affiliation

We report an efficient radical-based and photocatalyst-free method for the C(sp²)–C(sp³) cross-coupling reaction to synthesize α-aryl ester derivatives. The process starts from a β-keto ester and an electron-deficient halogenated aryl halide under alkaline conditions to form an electron donor–acceptor complex and is driven by visible light. From the synthetic point of view, this newly established method represents a simple way to access arylpropionic acids from commercially available and cheap starting materials.

中文翻译：

可见光介导通过 EDA 配合物合成 α-芳基酯衍生物

我们报道了一种有效的基于自由基且无光催化剂的C(sp ² )–C(sp ³ )交叉偶联反应合成α-芳基酯衍生物的方法。该过程从β-酮酯和缺电子的卤代芳基卤化物在碱性条件下形成电子供体-受体复合物开始，并由可见光驱动。从合成的角度来看，这种新建立的方法代表了一种从市售且廉价的起始原料中获取芳基丙酸的简单方法。

更新日期：2023-08-16

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