Activated Metals to Generate Heat for Biomedical Applications,ACS Materials Letters

当前位置： X-MOL 学术 › ACS Mater. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Activated Metals to Generate Heat for Biomedical Applications
ACS Materials Letters ( IF 9.6 ) Pub Date : 2023-08-16 , DOI: 10.1021/acsmaterialslett.3c00581
Eva Remlova _{1,

2} , Vivian Rachel Feig _{1,

3} , Ziliang Kang _{1,

4} , Ashka Patel _{1,

5} , Ian Ballinger ₁ , Anna Ginzburg _{1,

6} , Johannes Kuosmanen ₄ , Niora Fabian _{4,

7} , Keiko Ishida _{1,

3} , Joshua Jenkins _{1,

4} , Alison Hayward _{1,

4,

7} , Giovanni Traverso _{1,

3,

4}

Affiliation

Delivering heat in vivo could enhance a wide range of biomedical therapeutic and diagnostic technologies, including long-term drug delivery devices and cancer treatments. To date, providing thermal energy is highly power-intensive, rendering it oftentimes inaccessible outside of clinical settings. We developed an in vivo heating method based on the exothermic reaction between liquid-metal-activated aluminum and water. After establishing a method for consistent activation, we characterized the heat generation capabilities with thermal imaging and heat flux measurements. We then demonstrated one application of this reaction: to thermally actuate a gastric resident device made from a shape-memory alloy called Nitinol. Finally, we highlight the advantages and future directions for leveraging this novel in situ heat generation method beyond the showcased example.

中文翻译：

用于生物医学应用的活性金属产生热量

在体内传递热量可以增强广泛的生物医学治疗和诊断技术，包括长期药物输送设备和癌症治疗。迄今为止，提供热能是高度耗能的，因此在临床环境之外通常无法获得。我们开发了一种基于液态金属活化铝与水之间放热反应的体内加热方法。在建立了一致激活的方法后，我们通过热成像和热通量测量表征了发热能力。然后，我们演示了该反应的一个应用：热驱动由称为镍钛合金的形状记忆合金制成的胃驻留装置。最后，我们强调了在展示的示例之外利用这种新型原位生热方法的优势和未来方向。

更新日期：2023-08-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南