A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy,Phytomedicine

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A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy
Phytomedicine ( IF 6.7 ) Pub Date : 2023-08-16 , DOI: 10.1016/j.phymed.2023.155035
Martyna Nowak-Perlak ₁ , Piotr Ziółkowski ₁ , Marta Woźniak ₁

Affiliation

Background

Experimental studies emphasize the therapeutic potential of plant-derived photosensitizers used in photodynamic therapy. Moreover, several in vitro and in vivo research present the promising roles of less-known anthraquinones that can selectively target cancer cells and eliminate them after light irradiation. This literature review summarizes the current knowledge of chosen plant-based-photosensitizers in PDT to show the results of emodin, aloe-emodin, parietin, rubiadin, hypericin, and soranjidiol in photodynamic therapy of cancer treatment and describe the comprehensive perspective of their role as natural photosensitizers.

Methods

Literature searches of chosen anthraquinones were conducted on PubMed.gov with keywords: “emodin”, “aloe-emodin”, “hypericin”, “parietin”, “rubiadin”, “soranjidiol” with ”cancer” and “photodynamic therapy”.

Results

According to literature data, this review concentrated on all existing in vitro and in vivo studies of emodin, aloe-emodin, parietin, rubiadin, soranjidiol used as natural photosensitizers emphasizing their effectiveness and detailed mechanism of action in anticancer therapy. Moreover, comprehensive preclinical and clinical studies on hypericin reveal that the above-described substances may be included in the phototoxic treatment of different cancers.

Conclusions

Overall, this review presented less-known anthraquinones with their promising molecular mechanisms of action. It is expected that in the future they may be used as natural PSs in cancer treatment as well as hypericin.

中文翻译：

光动力疗法介导的一种有前景的天然蒽醌抗癌治疗

背景

实验研究强调了植物源光敏剂在光动力疗法中的治疗潜力。此外，一些体外和体内研究展示了鲜为人知的蒽醌的有前途的作用，它们可以选择性地靶向癌细胞并在光照射后消除它们。本文献综述总结了目前PDT中选择的植物基光敏剂的知识，展示了大黄素、芦荟大黄素、parietin、茜草素、金丝桃素和索兰吉二醇在癌症光动力疗法中的结果，并从综合角度描述了它们的作用：天然光敏剂。