Direct Acylation of Unactivated Alkyl Halides with Aldehydes through N-Heterocyclic Carbene Organocatalysis,Angewandte Chemie International Edition

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Direct Acylation of Unactivated Alkyl Halides with Aldehydes through N-Heterocyclic Carbene Organocatalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-08-15 , DOI: 10.1002/anie.202309572
Qing-Zhu Li ₁ , Rong Zeng _{1,

2} , Peng-Shuai Xu ₁ , Xin-Hang Jin ₁ , Chuan Xie ₁ , Qi-Chun Yang ₁ , Xiang Zhang ₁ , Jun-Long Li ₁

Affiliation

Aldehydes underwent cross-coupling with unactivated alkyl halides in the presence of an NHC organocatalyst, thus enabling the rapid synthesis of various ketones from readily available starting materials under mild conditions. This method was also applied to the late-stage functionalization of pharmaceutical derivatives. Mechanistic investigations suggest a closed-shell nucleophilic substitution mechanism for this organocatalytic reaction.

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