The world has faced climate change that affects hydrology and thermal systems in the aquatic environment resulting in temperature changes, which directly affect the aquatic ecosystem. Elevated water temperature influences the physico-chemical properties of chemicals in freshwater ecosystems leading to disturbing living organisms. Owing to the industrial revolution, the mass production of zinc oxide (ZnO) has been led to contaminated environments, and therefore, the toxicological effects of ZnO become more concerning under climate change scenarios. A comprehensive understanding of its toxicity influenced by main factors driven by climate change is indispensable. This review summarized the detrimental effects of ZnO with a single ZnO exposure and combined it with key climate change-associated factors in many aspects (i.e., oxidative stress, energy reserves, behavior and life history traits). Moreover, this review tried to point out ZnO kinetic behavior and corresponding mechanisms which pose a problem of observed detrimental effects correlated with the alteration of elevated temperature.