We have described herein a metal-free one-pot synthesis of indolizin-1-yl-pyrimidines from ethyl 3-(3-ethoxy-3-oxopropanoyl) indolizine-1-carboxylate, DMF-DMA and amidines. This protocol provides the tethering of indolizine scaffold with various 2-substitutted pyrimidines using simple starting materials. This new chemo-types may be useful in drug discovery and material science exploration.

中文翻译：

---

3-(3-乙氧基-3-氧代丙酰)中氮茚-1-甲酸乙酯、DMF-DMA和脒一锅合成中氮茚-1-基-嘧啶

我们在此描述了由3-(3-乙氧基-3-氧代丙酰基)中氮茚-1-甲酸乙酯、DMF-DMA和脒进行中氮茚-1-基-嘧啶的无金属一锅合成。该方案使用简单的起始材料提供了中氮茚支架与各种2-取代嘧啶的束缚。这种新的化学类型可能有助于药物发现和材料科学探索。