The development of an improved manufacturing process for the active ingredient vilanterol trifenatate, a potent drug for the treatment of chronic obstructive pulmonary disease (COPD), has been described with high yield and purity. The robust process was demonstrated on a multi kilogram scale. Wiped Film Molecular Distillation was applied to purify intermediates that were easily decomposed at high temperature, improving the yield by 10–15%. Meanwhile, the corresponding impurity was studied in detail and well resolved. Finally, vilanterol trifenatate was obtained pure in a very competitive total of 6 steps with a yield of 57.9%, and it was crystallized with greater than 99.9% purity, 99.9% chiral purity and no single major impurity >0.1%.

活性成分维兰特罗三芬那酯是一种治疗慢性阻塞性肺病(COPD) 的有效药物，其改进的生产工艺已得到开发，具有高产率和纯度。这个稳健的过程在公斤规模上得到了证明。采用刮膜分子蒸馏法纯化高温下易分解的中间体，收率提高10%~15%。同时对相应的杂质进行了详细的研究并得到了很好的解决。最终，通过极具竞争力的总共 6 个步骤，获得了纯的维兰特罗三芬酯，收率为 57.9%，并且结晶纯度大于 99.9%，手性纯度为 99.9%，且没有单一主要杂质 >0.1%。