Ovarian cancer (OC) has the highest mortality rate among female reproductive system tumours, with limited efficacy of traditional treatments and 5-year survival rates that rarely exceed 40%. Circular RNA (circRNA) is a stable endogenous circular RNA that typically regulates protein expression by binding to downstream miRNA. It has been demonstrated that circRNAs play an important role in the proliferation, migration, and glucose metabolism (such as the Warburg effect) of OC and can regulate the expression of glucose metabolism-related proteins such as GLUT1 and HK2, promoting anaerobic glycolysis of cancer cells, increasing glucose uptake and ATP production, and affecting energy supply and biosynthetic substances to support tumour growth and invasion. This review summarises the formation and characteristics of circRNAs and focuses on their role in regulating glucose metabolism in OC cells and their potential therapeutic value, providing insights for identifying new therapeutic targets.

卵巢癌（OC）是女性生殖系统肿瘤中死亡率最高的癌症，传统治疗的疗效有限，5年生存率很少超过40%。环状 RNA (circRNA) 是一种稳定的内源性环状 RNA，通常通过与下游 miRNA 结合来调节蛋白质表达。研究表明，circRNA在OC的增殖、迁移和糖代谢（如Warburg效应）中发挥重要作用，并能调节GLUT1和HK2等糖代谢相关蛋白的表达，促进癌症的无氧糖酵解细胞，增加葡萄糖摄取和 ATP 产生，并影响能量供应和生物合成物质以支持肿瘤生长和侵袭。本文总结了circRNA的形成和特征，重点讨论了它们在OC细胞中调节葡萄糖代谢的作用及其潜在的治疗价值，为识别新的治疗靶点提供了见解。