一种新的路易斯结构及其在有机化学反应机理研究中的应用,Journal of Chemical Education

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一种新的路易斯结构及其在有机化学反应机理研究中的应用
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2023-08-14 , DOI: 10.1021/acs.jchemed.3c00273
Weijie Zhou ₁ , Zhiyuan Xu ₂ , Junlong Zhao ₃

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尽管有机化学是许多理工科本科课程的必修课，但了解有机反应机制对于许多本科生来说是一项具有挑战性的任务，特别是那些非化学专业的学生。反应的选择性很大程度上取决于电子云的分布和偏差。尽管如此，传统的路易斯结构被证明不足以清楚地表达西格玛键、孤对电子和π键之间的区别和相关性。因此，对有机化合物的结构进行精确、彻底的科学分析具有重要意义。鉴于此，我们提出了一种表示化学键的开创性方法，这不仅可以更清晰地描述分子中的电子云偏差，还可以更直观地描述化合物结构和反应机制。根据提出的新颖的路易斯结构，我们在课堂上重新解释了有机化学反应的机理。本文按照反应的类型进行介绍并举例，包括亲核取代反应、亲核加成反应、亲电加成反应等。课后，我们对课堂体验和对反应的新认识进行了问卷调查。通过收集大学生的成绩（本文按照反应的类型进行介绍并举例，包括亲核取代反应、亲核加成反应、亲电加成反应等。课后，我们对课堂体验和对反应的新认识进行了问卷调查。通过收集大学生的成绩（本文按照反应的类型进行介绍并举例，包括亲核取代反应、亲核加成反应、亲电加成反应等。课后，我们对课堂体验和对反应的新认识进行了问卷调查。通过收集大学生的成绩（N = 300）的不同专业（N = 5），我们发现我们的方法可以显着提高他们对反应机制的理解（90％），帮助他们转移知识（82％），并提高学习效率（69％）。

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A Novel Lewis Structure and Its Utilization in the Examination of Mechanisms of Organic Chemical Reactions

Understanding organic reaction mechanisms can be a challenging task for many undergraduate students, particularly those who are nonchemistry majors, despite the fact that organic chemistry is a mandatory course for numerous science and engineering undergraduate programs. The selectivity of a reaction is largely determined by the distribution and deviation of electron clouds. Nonetheless, the traditional Lewis structure proves inadequate in clearly conveying the distinctions and correlations among sigma bonds, lone pair electrons, and pi bonds. Therefore, a precise and thorough scientific analysis of the structure of organic compounds is of great significance. In light of this, we propose a pioneering method for representing chemical bonds, which not only provides a more lucid portrayal of electron cloud deviation in molecules but also offers a more intuitive depiction of compound structure and reaction mechanisms. According to the proposed novel Lewis structure, we re-explained the mechanism of organic chemical reactions in class. This paper introduces and gives examples according to the types of reactions, including nucleophilic substitution reaction, nucleophilic addition reaction, and electrophilic addition reaction, etc. After class, we conducted a questionnaire survey on the classroom experience and new understanding of reaction. By collecting the results of college students (N = 300) of different majors (N = 5), we found that our method could significantly improved their understanding of reaction mechanisms (90%), help them transfer knowledge (82%), and improve learning efficiency (69%).

更新日期：2023-08-14

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