A Photo-Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual-Dynamic Cascade Cancer Therapy,Advanced Healthcare Materials

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A Photo-Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual-Dynamic Cascade Cancer Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-08-12 , DOI: 10.1002/adhm.202301469
Xu Zhang ₁ , Xinlu Zhang ₁ , Haizhen Guo ₁ , Shitian Jia ₁ , Yong Li ₁ , Suixin Xing ₁ , Jin Chang ₁ , Sheng Wang ₁

Affiliation

The special redox homeostasis of tumor cells makes reactive oxygen species (ROS)-based approaches a promising cancer therapeutic strategy. Among these approaches, photodynamic therapy is the most widely studied ROS-based treatment due to its ability to achieve targeted therapy by local light irradiation. However, achieving efficient and continuous ROS generation without prolonged laser exposure is still challenging. In this work, a photo-activated continuous ROS nanoamplifier is proposed for photodynamic–chemodynamic cascade therapy. Upon local laser irradiation, the nanoamplifier can continuously amplify cellular oxidative stress through a positive feedback loop of “light-triggered ROS generation, ROS-responsive prodrug activation, and Fenton reaction-mediated ROS cyclic regenerative amplification”, avoiding tissue damage caused by excessive laser exposure. This strategy provides a potential pathway to overcome the limitations of ROS-based therapeutic approaches.

中文翻译：

用于双动态级联癌症治疗的光激活连续活性氧纳米放大器

肿瘤细胞特殊的氧化还原稳态使得基于活性氧（ROS）的方法成为一种有前途的癌症治疗策略。在这些方法中，光动力疗法是研究最广泛的基于ROS的治疗方法，因为它能够通过局部光照射实现靶向治疗。然而，在不长时间激光照射的情况下实现高效、连续的 ROS 生成仍然具有挑战性。在这项工作中，提出了一种光激活连续 ROS 纳米放大器用于光动力-化学动力级联疗法。在局部激光照射下，纳米放大器可以通过“光触发ROS生成、ROS响应性前药激活和芬顿反应介导的ROS循环再生放大”的正反馈回路，持续放大细胞氧化应激，避免过度激光造成的组织损伤接触。该策略为克服基于 ROS 的治疗方法的局限性提供了一条潜在途径。

更新日期：2023-08-12

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