含有巨囊泡的咪唑表面活性离子液体中药用色素姜黄素的超快动力学和通过三重 FRET 技术产生白光,Langmuir

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含有巨囊泡的咪唑表面活性离子液体中药用色素姜黄素的超快动力学和通过三重 FRET 技术产生白光
Langmuir ( IF 3.7 ) Pub Date : 2023-08-11 , DOI: 10.1021/acs.langmuir.3c01233
Nanigopal Bera ₁ , Souvik Layek ₁ , Shashwata Pramanik ₁ , Pratyush Kiran Nandi ₁ , Ritwik Hazra ₁ , Nilmoni Sarkar ₁

Affiliation

天然存在的黄色多酚药用色素姜黄素在激发态下表现出超快的动力学。这些超快动力学受到系统环境刚性的强烈影响。目前的研究揭示了超快激发态分子内氢原子转移（ESIHT）（参与抗氧化机制）和姜黄素在咪唑鎓表面活性离子液体（SAIL）、1-十六烷基-3-甲基氯化咪唑鎓中的溶剂化动力学在水性介质中引入脱水山梨糖醇单酯（Span 20 和 Span 80）后的（[C _{16 mim]Cl）胶束和巨型囊泡。}有趣的是，含有Span 20的短烃链形成更小、刚性较低的囊泡，而含有Span 80的长烃链在与[C 16 mim]Cl组装后形成更大、更刚性的巨型_囊泡。含有刚性囊泡的 Span 80 中的 ESIHT 和溶剂化动力学比含有较少刚性囊泡的 Span 20 中慢。最后，我们建立了三组分荧光共振能量转移（Triple-FRET）系统，以在胶束和巨型囊泡中产生白光（WL）。这里，疏水性染料 1,6-二苯基-1,3,5-己三烯 (DPH) 充当供体，亲水性抗癌药物盐酸阿霉素 (DOX) 与中间供体姜黄素一起充当受体。在特定自组装系统中这些染料浓度的特定组合下，由于三重 FRET 现象而产生 WL。

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Ultrafast Dynamics of the Medicinal Pigment Curcumin inside the Imidazolium Surface Active Ionic Liquid Containing Giant Vesicles and White Light Generation via Triple-FRET Technique

The naturally occurring yellow polyphenolic medicinal pigment curcumin shows ultrafast dynamics in the excited states. These ultrafast dynamics are strongly influenced by the rigidity of the environments of the systems. The present investigation unveils the ultrafast excited-state intramolecular hydrogen atom transfer (ESIHT) (which is involved in the antioxidant mechanism) and the solvation dynamics of curcumin inside the imidazolium surface active ionic liquid (SAIL), 1-hexadecyl-3-methylimidazolium chloride ([C₁₆mim]Cl) micelle, and giant vesicles after introducing sorbitan monoesters (Span 20 and Span 80) in the aqueous medium. Interestingly, the short hydrocarbon chain containing Span 20 forms smaller, less rigid vesicles, and the long hydrocarbon chain containing Span 80 forms larger, more rigid giant vesicles after being assembled with [C₁₆mim]Cl. The ESIHT and the solvation dynamics are slower in Span 80, containing rigid vesicles, than that in Span 20, comprising less rigid vesicles. Finally, we have established a three-component fluorescence resonance energy transfer (Triple-FRET) system to generate white light (WL) in the micelle and giant vesicles. Here the hydrophobic dye 1,6-diphenyl-1,3,5-hexatriene (DPH) acts as the donor, and the hydrophilic anticancer drug doxorubicin hydrochloride (DOX) serves as the acceptor along with the intermediate donor, curcumin. At a specific combination of the concentrations of these dyes in a particular self-assembled system, WL is generated due to the triple-FRET phenomena.

更新日期：2023-08-11

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